Publications

Found 1661 results
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2020
He, H., Bian, G., Herbst-Gervasoni, C. J., Mori, T., Shinsky, S. A., Hou, A., Mu, X., Huang, M., Cheng, S., Deng, Z., Christianson, D. W., Abe, I., and Liu, T. (2020) Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nat Commun. 11, 3958
Adam, S., Anteneh, H., Hornisch, M., Wagner, V., Lu, J., Radde, N. E., Bashtrykov, P., Song, J., and Jeltsch, A. (2020) DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation. Nat Commun. 11, 3723
Moreno, M. V., Rockwell, N. C., Mora, M., Fisher, A. J., and J Lagarias, C. (2020) A far-red cyanobacteriochrome lineage specific for verdins. Proc Natl Acad Sci U S A. 10.1073/pnas.2016047117
Li, Y. L., Zee, C. - T., Lin, J. B., Basile, V. M., Muni, M., Flores, M. D., Munárriz, J., Kaner, R. B., Alexandrova, A. N., Houk, K. N., Tolbert, S. H., and Rubin, Y. (2020) Fjord-Edge Graphene Nanoribbons with Site-Specific Nitrogen Substitution. J Am Chem Soc. 142, 18093-18102
Li, Y. L., Zee, C. - T., Lin, J. B., Basile, V. M., Muni, M., Flores, M. D., Munárriz, J., Kaner, R. B., Alexandrova, A. N., Houk, K. N., Tolbert, S. H., and Rubin, Y. (2020) Fjord-Edge Graphene Nanoribbons with Site-Specific Nitrogen Substitution. J Am Chem Soc. 142, 18093-18102
Posternak, G., Tang, X., Maisonneuve, P., Jin, T., Lavoie, H., Daou, S., Orlicky, S., de Rugy, T. Goullet, Caldwell, L., Chan, K., Aman, A., Prakesch, M., Poda, G., Mader, P., Wong, C., Maier, S., Kitaygorodsky, J., Larsen, B., Colwill, K., Yin, Z., Ceccarelli, D. F., Batey, R. A., Taipale, M., Kurinov, I., Uehling, D., Wrana, J., Durocher, D., Gingras, A. - C., Al-awar, R., Therrien, M., and Sicheri, F. (2020) Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat Chem Biol. 10.1038/s41589-020-0609-7
Posternak, G., Tang, X., Maisonneuve, P., Jin, T., Lavoie, H., Daou, S., Orlicky, S., de Rugy, T. Goullet, Caldwell, L., Chan, K., Aman, A., Prakesch, M., Poda, G., Mader, P., Wong, C., Maier, S., Kitaygorodsky, J., Larsen, B., Colwill, K., Yin, Z., Ceccarelli, D. F., Batey, R. A., Taipale, M., Kurinov, I., Uehling, D., Wrana, J., Durocher, D., Gingras, A. - C., Al-awar, R., Therrien, M., and Sicheri, F. (2020) Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat Chem Biol. 10.1038/s41589-020-0609-7
Coleman, R. E., Vilbert, A. C., and Lancaster, K. M. (2020) The Heme-Lys Cross-Link in Cytochrome P460 Promotes Catalysis by Enforcing Secondary Coordination Sphere Architecture. Biochemistry. 59, 2289-2298
Easterhoff, D., Pollara, J., Luo, K., Janus, B., Gohain, N., Williams, L. T. D., Tay, M. Zirui, Monroe, A., Peachman, K., Choe, M., Min, S., Lusso, P., Zhang, P., Go, E. P., Desaire, H., Bonsignori, M., Hwang, K. - K., Beck, C., Kakalis, M., O'Connell, R. J., Vasan, S., Kim, J. H., Michael, N. L., Excler, J. - L., Robb, M. L., Rerks-Ngarm, S., Kaewkungwal, J., Pitisuttithum, P., Nitayaphan, S., Sinangil, F., Tartaglia, J., Phogat, S., Wiehe, K., Saunders, K. O., Montefiori, D. C., Tomaras, G. D., M Moody, A., Arthos, J., Rao, M., M Joyce, G., Ofek, G., Ferrari, G., and Haynes, B. F. (2020) HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight. 10.1172/jci.insight.131437
Easterhoff, D., Pollara, J., Luo, K., Janus, B., Gohain, N., Williams, L. T. D., Tay, M. Zirui, Monroe, A., Peachman, K., Choe, M., Min, S., Lusso, P., Zhang, P., Go, E. P., Desaire, H., Bonsignori, M., Hwang, K. - K., Beck, C., Kakalis, M., O'Connell, R. J., Vasan, S., Kim, J. H., Michael, N. L., Excler, J. - L., Robb, M. L., Rerks-Ngarm, S., Kaewkungwal, J., Pitisuttithum, P., Nitayaphan, S., Sinangil, F., Tartaglia, J., Phogat, S., Wiehe, K., Saunders, K. O., Montefiori, D. C., Tomaras, G. D., M Moody, A., Arthos, J., Rao, M., M Joyce, G., Ofek, G., Ferrari, G., and Haynes, B. F. (2020) HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight. 10.1172/jci.insight.131437
Harvey, E. P., Hauseman, Z. J., Cohen, D. T., T Rettenmaier, J., Lee, S., Huhn, A. J., Wales, T. E., Seo, H. - S., Luccarelli, J., Newman, C. E., Guerra, R. M., Bird, G. H., Dhe-Paganon, S., Engen, J. R., Wells, J. A., and Walensky, L. D. (2020) Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 27, 647-656.e6
Harvey, E. P., Hauseman, Z. J., Cohen, D. T., T Rettenmaier, J., Lee, S., Huhn, A. J., Wales, T. E., Seo, H. - S., Luccarelli, J., Newman, C. E., Guerra, R. M., Bird, G. H., Dhe-Paganon, S., Engen, J. R., Wells, J. A., and Walensky, L. D. (2020) Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 27, 647-656.e6
Pinch, B. J., Doctor, Z. M., Nabet, B., Browne, C. M., Seo, H. - S., Mohardt, M. L., Kozono, S., Lian, X., Manz, T. D., Chun, Y., Kibe, S., Zaidman, D., Daitchman, D., Yeoh, Z. C., Vangos, N. E., Geffken, E. A., Tan, L., Ficarro, S. B., London, N., Marto, J. A., Buratowski, S., Dhe-Paganon, S., Zhou, X. Zhen, Lu, K. Ping, and Gray, N. S. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 16, 979-987
Pinch, B. J., Doctor, Z. M., Nabet, B., Browne, C. M., Seo, H. - S., Mohardt, M. L., Kozono, S., Lian, X., Manz, T. D., Chun, Y., Kibe, S., Zaidman, D., Daitchman, D., Yeoh, Z. C., Vangos, N. E., Geffken, E. A., Tan, L., Ficarro, S. B., London, N., Marto, J. A., Buratowski, S., Dhe-Paganon, S., Zhou, X. Zhen, Lu, K. Ping, and Gray, N. S. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 16, 979-987
Pinch, B. J., Doctor, Z. M., Nabet, B., Browne, C. M., Seo, H. - S., Mohardt, M. L., Kozono, S., Lian, X., Manz, T. D., Chun, Y., Kibe, S., Zaidman, D., Daitchman, D., Yeoh, Z. C., Vangos, N. E., Geffken, E. A., Tan, L., Ficarro, S. B., London, N., Marto, J. A., Buratowski, S., Dhe-Paganon, S., Zhou, X. Zhen, Lu, K. Ping, and Gray, N. S. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 16, 979-987
Bhardwaj, R., Lindinger, S., Neuberger, A., Nadezhdin, K. D., Singh, A. K., Cunha, M. R., Derler, I., Gyimesi, G., Reymond, J. - L., Hediger, M. A., Romanin, C., and Sobolevsky, A. I. (2020) Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv. 10.1126/sciadv.abe1508
Zhong, M., Lynch, A., Muellers, S. N., Jehle, S., Luo, L., Hall, D. R., Iwase, R., Carolan, J. P., Egbert, M., Wakefield, A., Streu, K., Harvey, C. M., Ortet, P. C., Kozakov, D., Vajda, S., Allen, K. N., and Whitty, A. (2020) Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2). Biochemistry. 10.1021/acs.biochem.9b00943
Zhong, M., Lynch, A., Muellers, S. N., Jehle, S., Luo, L., Hall, D. R., Iwase, R., Carolan, J. P., Egbert, M., Wakefield, A., Streu, K., Harvey, C. M., Ortet, P. C., Kozakov, D., Vajda, S., Allen, K. N., and Whitty, A. (2020) Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2). Biochemistry. 10.1021/acs.biochem.9b00943
Nelson, A. C., Turbyville, T. J., Dharmaiah, S., Rigby, M., Yang, R., Wang, T. - Y., Columbus, J., Stephens, R., Taylor, T., Sciacca, D., Onsongo, G., Sarver, A., Subramanian, S., Nissley, D. V., Simanshu, D. K., and Lou, E. (2020) internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J Biol Chem. 10.1074/jbc.RA119.011080
Rudolph, M. J., Czajka, T. F., Davis, S. A., Nguyen, C. My Thi, Li, X. - P., Tumer, N. E., Vance, D. J., and Mantis, N. J. (2020) Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J Mol Biol. 10.1016/j.jmb.2020.01.006
Sherkhanov, S., Korman, T. P., Chan, S., Faham, S., Liu, H., Sawaya, M. R., Hsu, W. - T., Vikram, E., Cheng, T., and Bowie, J. U. (2020) Isobutanol production freed from biological limits using synthetic biochemistry. Nat Commun. 11, 4292
Geiger, T., Lara-Tejero, M., Xiong, Y., and Galán, J. E. (2020) Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase. Elife. 10.7554/eLife.53473
Guzman, M., Rugel, A., Tarpley, R. S., Cao, X., McHardy, S. F., LoVerde, P. T., and Taylor, A. B. (2020) Molecular basis for hycanthone drug action in schistosome parasites. Mol Biochem Parasitol. 236, 111257
Das, A., Hand, T. H., Smith, C. L., Wickline, E., Zawrotny, M., and Li, H. (2020) The molecular basis for recognition of 5'-NNNCC-3' PAM and its methylation state by Acidothermus cellulolyticus Cas9. Nat Commun. 11, 6346
Kosciuk, T., Price, I. R., Zhang, X., Zhu, C., Johnson, K. N., Zhang, S., Halaby, S. L., Komaniecki, G. P., Yang, M., DeHart, C. J., Thomas, P. M., Kelleher, N. L., J Fromme, C., and Lin, H. (2020) NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 11, 1067

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