Publications
(2015) Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science. 350, aab4070
(2014) Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 57, 7016-30
(2014) Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 5, 4202
(2014) Structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase holoenzyme reveals a novel surface. Acta Crystallogr F Struct Biol Commun. 70, 1333-9
(2012) Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc Natl Acad Sci U S A. 109, 14779-84
(2011) The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. J Biol Chem. 286, 20930-41
(2011) Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A. 108, 11896-9
(2011) Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 145, 692-706
(2011) Structural basis for human PHF2 Jumonji domain interaction with metal ions. J Mol Biol. 406, 1-8
(2010) Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB. J Struct Biol. 170, 501-12
(2008) The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A. 105, 17742-7
(2008) Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 130, 11570-1
(2006) Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proc Natl Acad Sci U S A. 103, 4028-33
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