Publications

Found 5 results
Filters: Author is Meeks, Kaylen R  [Clear All Filters]
2023
Daudu, O. I., Meeks, K. R., Zhang, L., Seravalli, J., Tanner, J. J., and Becker, D. F. (2023) Functional Impact of a Cancer-Related Variant in Human Δ-Pyrroline-5-Carboxylate Reductase 1.. ACS Omega. 8, 3509-3519
2024
Meeks, K. R., Bogner, A. N., Nix, J. C., and Tanner, J. J. (2024) Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase.. Molecules. 10.3390/molecules29225408
Meeks, K. R., Ji, J., Protopopov, M. V., Tarkhanova, O. O., Moroz, Y. S., and Tanner, J. J. (2024) Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J Chem Inf Model. 64, 1704-1718
Meeks, K. R., Bogner, A. N., and Tanner, J. J. (2024) Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1). Protein Sci. 33, e5072
2026
Meeks, K. R., Mattingly, C. J., Nix, J. C., Chuk, O., Protopopov, M. V., Tarkhanova, O. O., and Tanner, J. J. (2026) Serendipitous Discovery of an Allosteric Inhibitor Binding Groove in the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 1 (PYCR1). Biochem J. 10.1042/BCJ20250278