Publications

Found 4 results
Filters: Author is Singer, Alexander U  [Clear All Filters]
2023
Bruce, H. A., Singer, A. U., Filippova, E. V., Blazer, L. L., Adams, J. J., Enderle, L., Ben-David, M., Radley, E. H., Mao, D. Y. L., Pau, V., Orlicky, S., Sicheri, F., Kourinov, I., Atwell, S., Kossiakoff, A. A., and Sidhu, S. S. (2023) Engineered Antigen-Binding Fragments for Enhanced Crystallization of Antibody:Antigen Complexes. Protein Sci. 10.1002/pro.4824
2024
Bruce, H. A., Singer, A. U., Blazer, L. L., Luu, K., Ploder, L., Pavlenco, A., Kurinov, I., Adams, J. J., and Sidhu, S. S. (2024) Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci. 33, e5081
2025
Adams, J. J., Blazer, L. L., Chung, J., Karimi, M., Davidson, T., Bruce, H. A., Singer, A. U., Yang, N., Cardarelli, L., Pot, I., Colombo, L., Huang, L. Jun- Shen, Ma, Y., Michnick, S. W., Moe, O. W., and Sidhu, S. S. (2025) An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo. Protein Sci. 34, e70292
Adams, J. J., Bruce, H. A., Subramania, S., Ploder, L., Garcia, J., Pot, I., Blazer, L. L., Singer, A. U., and Sidhu, S. S. (2025) Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation. Protein Sci. 34, e70145