Publications

Found 187 results
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2025
Liu, H., Zask, A., Forouhar, F., Iketani, S., Williams, A., Vaz, D. R., Habashi, D., Choi, K., Resnick, S. J., Hong, S. Jung, Lovett, D. H., Bai, T., Chavez, A., Ho, D. D., and Stockwell, B. R. (2025) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
Miranda, R., Anson, F., Smith, S. T., Ultsch, M., Tenorio, C. A., Rougé, L., Farrell, B., Adaligil, E., Holden, J. K., Harris, S. F., and Dueber, E. C. (2025) Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7. Structure. 10.1016/j.str.2025.01.021
Tresco, B. I. C., J Y Wu, K., Ramkissoon, A., Aleksandrova, E. V., Purdy, M., N Y See, D., Liu, R. Y., Polikanov, Y. S., and Myers, A. G. (2025) Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis. Nat Chem. 10.1038/s41557-025-01738-7
Bergman, H. M., Fan, A. T., Jones, C. G., Rothenberger, A. J., Jha, K. K., Handford, R. C., Nelson, H. M., Liu, Y., and T Tilley, D. (2025) Discovery of an Interlocked and Interwoven Molecular Topology in Nanocarbons via Dynamic C-C Bond Formation. J Am Chem Soc. 147, 19132-19138
Nguyen, B. V., Özden, C., Dong, K., Koc, O. Can, Torres-Ocampo, A. P., Dziedzic, N., Flaherty, D., Huang, J., Sankara, S., Abromson, N. Lyn, Tomchick, D. R., Fissore, R. A., Chen, J., Garman, S. C., and Stratton, M. M. (2025) A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. Nat Commun. 16, 8461
Ma, J., Ayres, C. M., Brambley, C. A., Chandran, S. S., Rosales, T. J., Perera, W. W. J. Gihan, Eldaly, B., Murray, W. T., Corcelli, S. A., Kovrigin, E. L., Klebanoff, C. A., and Baker, B. M. (2025) Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity. Nat Commun. 16, 849
2026
Bubenik, M., Mader, P., Orlicky, S., Perryman, A. L., Hamel, M., Godbout, C., Falgueyret, J. - P., Kurinov, I., Wong, C., Gingras, A. Claude, Mamane, Y., Zinda, M., Morris, S. J., Gallant, M., Sfeir, A., W Black, C., Durocher, D., Zimmermann, M., and Sicheri, F. (2026) Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.. ACS Med Chem Lett. 17, 433-440
Smil, D., Liu, Y., Xin, T., Kiyota, T., Aman, A., Grouleff, J., Hoffer, L., Joshi, D. C., Inanlou, M. R., Song, S., Mao, D. Y. L., Ogunjimi, A. A., Pau, V., Chini, F. D., Kurinov, I., Zhang, Y., Nguyen, A. Thu, Wrana, J. L., Sicheri, F., Attisano, L., Uehling, D., Al-awar, R., and Isaac, M. B. (2026) Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer. Eur J Med Chem. 311, 118798
Landry, M. L., Malhotra, S., Beresini, M., Chan, C., Chan, E., de la Cruz, C. C., Endres, N. F., Evangelista, M., Gustafson, A., Hu, D., Hunsaker, T., Hsu, P., Izrayelit, Y., La, H., Larrocha, P. Saenz- Lope, Lian, Q., Merchant, M., Mao, J., Mroue, R., Oh, A., Plise, E., Shao, C., Siu, M., Tran, J. C., Wang, Y., Wang, W., Wei, B., Wong, S., Yen, C. - W., Zhou, Y., Purkey, H. E., Heffron, T. P., and Salphati, L. (2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
Chen, H., Dutta, R. Prasad, Li, Z., Zhong, Y., Ma, A., Park, K. - S., Kottur, J., Park, A., Babault, N., Wang, K., Wang, D., Xiong, Y., H Kaniskan, Ü., Luo, M., Parekh, S., and Jin, J. (2026) Discovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8. J Med Chem. 69, 4255-4269
Shamir, Y., Gabizon, R., Rogel, A., Lin, D. Yin-wei, Andreotti, A. H., and London, N. (2026) Discovery of Covalent Ligands with AlphaFold3. J Am Chem Soc. 148, 13043-13054
Huet-Calderwood, C., Fisher, O. S., Das, S., Su, V. L., Boggon, T. J., and Calderwood, D. A. (2026) Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression. Nat Commun. 10.1038/s41467-026-69595-7

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