Publications
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP. Structure. 30, 1603-1614.e5
(2022) (2022) (2022) (2022) (2021)
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 10.1016/j.pbiomolbio.2021.02.002
(2021) Thermal stability and structure of glyceraldehyde-3-phosphate dehydrogenase from the coral . RSC Adv. 11, 10364-10374
(2021) Transferrin receptor targeting by de novo sheet extension. Proc Natl Acad Sci U S A. 10.1073/pnas.2021569118
(2021) (2021) Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 10.1016/j.chembiol.2020.02.003
(2020) Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors. Bioorg Med Chem Lett. 30, 127292
(2020) Termini restraining of small membrane proteins enables structure determination at near-atomic resolution. Sci Adv. 10.1126/sciadv.abe3717
(2020) The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling. J Immunol. 204, 58-67
(2020) The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites. J Mol Biol. 10.1016/j.jmb.2020.08.025
(2020) Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.. Cell Rep. 32, 107922
(2020) The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase. Nat Commun. 11, 4437
(2020) Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics. J Biol Chem. 10.1074/jbc.RA120.014750
(2020) TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun. 11, 547
(2020) The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding. Biosci Rep. 10.1042/BSR20193360
(2020) Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells. Toxins (Basel). 10.3390/toxins12100616
(2020) Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins. 87, 1037-1057
(2019) Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure. 10.1016/j.str.2019.01.008
(2019) Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature. 565, 112-117
(2019) Tuning Radical Relay Residues by Proton Management Rescues Protein Electron Hopping. J Am Chem Soc. 141, 17571-17587
(2019) T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction. Nucleic Acids Res. 10.1093/nar/gky776
(2018)