Publications

Found 2722 results
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Chehayeb, R. Jaber, Stiegler, A. L., and Boggon, T. J. (2019) Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. PLoS One. 14, e0226113
Chehayeb, R. Jaber, Wang, J., Stiegler, A. L., and Boggon, T. J. (2020) The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J Biol Chem. 295, 10511-10521
Chen, L., Shi, K., Yin, Z., and Aihara, H. (2013) Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution. Nucleic Acids Res. 41, 648-56
Chen, Y., Seepersaud, R., Bensing, B. A., Sullam, P. M., and Rapoport, T. A. (2016) Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 113, E1190-9
Chen, C., Ha, B. Hak, Thévenin, A. F., Lou, H. Jane, Zhang, R., Yip, K. Y., Peterson, J. R., Gerstein, M., Kim, P. M., Filippakopoulos, P., Knapp, S., Boggon, T. J., and Turk, B. E. (2014) Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Mol Cell. 53, 140-7
Chen, M., Chou, W. K. W., Toyomasu, T., Cane, D. E., and Christianson, D. W. (2016) Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. ACS Chem Biol. 11, 889-99
Chen, W. - H., Hajduczki, A., Martinez, E. J., Bai, H., Matz, H., Hill, T. M., Lewitus, E., Chang, W. C., Dawit, L., Peterson, C. E., Rees, P. A., Ajayi, A. B., Golub, E. S., Swafford, I., Dussupt, V., David, S., Mayer, S. V., Soman, S., Kuklis, C., Corbitt, C., King, J., Choe, M., Sankhala, R. S., Thomas, P. V., Zemil, M., Wieczorek, L., Hart, T., Duso, D., Kummer, L., Yan, L., Sterling, S. L., Laing, E. D., Broder, C. C., Williams, J. K., Davidson, E., Doranz, B. J., Krebs, S. J., Polonis, V. R., Paquin-Proulx, D., Rolland, M., Reiley, W. W., Gromowski, G. D., Modjarrad, K., Dooley, H., and M Joyce, G. (2023) Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity. Nat Commun. 14, 580
Chen, M. (2016) Terpene Synthases: One Fold, Many Products. Ph.D. thesis, University of Pennsylvania, Philadelphia, Pennsylvania
Chen, E. V., Nicoludis, J. M., Powell, B. M., Li, K. S., and Yatsunyk, L. A. (2023) Crystal structure of a three-tetrad, parallel, K-stabilized human telomeric G-quadruplex at 1.35 Å resolution.. Acta Crystallogr F Struct Biol Commun. 79, 144-150
Chen, M., Chou, W. K. W., Al-Lami, N., Faraldos, J. A., Allemann, R. K., Cane, D. E., and Christianson, D. W. (2016) Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry. 55, 2864-74
Chen, B., Basak, S., Chen, P., Zhang, C., Perry, K., Tian, S., Yu, C., Dong, M., Huang, L., Bowen, M. E., and Jin, R. (2022) Structure and conformational dynamics of toxin A. Life Sci Alliance. 10.26508/lsa.202201383
Chen, Y., Farquhar, E. R., Chance, M. R., Palczewski, K., and Kiser, P. D. (2012) Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 287, 13356-70
Chen, S., Tjin, C. Chandra, Gao, X., Xue, Y., Jiao, H., Zhang, R., Wu, M., He, Z., Ellman, J., and Ha, Y. (2021) Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.. Proc Natl Acad Sci U S A. 10.1073/pnas.2002486118
Chen, C. - W., Leimer, N., Syroegin, E. A., Dunand, C., Bulman, Z. P., Lewis, K., Polikanov, Y. S., and Svetlov, M. S. (2023) Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nat Commun. 14, 4196
Chen, G., Liu, Y., Goetz, R., Fu, L., Jayaraman, S., Hu, M. - C., Moe, O. W., Liang, G., Li, X., and Mohammadi, M. (2018) α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.. Nature. 10.1038/nature25451
Chen, Y., Bauer, B. W., Rapoport, T. A., and Gumbart, J. C. (2015) Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 427, 2348-59
Chen, C. - W., Pavlova, J. A., Lukianov, D. A., Tereshchenkov, A. G., Makarov, G. I., Khairullina, Z. Z., Tashlitsky, V. N., Paleskava, A., Konevega, A. L., Bogdanov, A. A., Osterman, I. A., Sumbatyan, N. V., and Polikanov, Y. S. (2021) Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome. Antibiotics (Basel). 10.3390/antibiotics10040390
Chen, Z., Yang, H., and Pavletich, N. P. (2008) Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures. Nature. 453, 489-4
Chen, Y., Rajashankar, K. R., Yang, Y., Agnihothram, S. S., Liu, C., Lin, Y. - L., Baric, R. S., and Li, F. (2013) Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus. J Virol. 87, 10777-83
Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. - H., Liu, Z., He, X., Perry, K., Dong, M., and Jin, R. (2018) Structural basis for recognition of frizzled proteins by toxin B. Science. 360, 664-669
Chen, P. Yang- Ting, Li, B., Drennan, C. L., and Elliott, S. J. (2019) A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO. Joule. 3, 595-611
Chen, M., Drury, J. E., Christianson, D. W., and Penning, T. M. (2012) Conversion of human steroid 5β-reductase (AKR1D1) into 3β-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering.. J Biol Chem. 287, 16609-22
Chen, X., Kim, T. Doohun, Carman, C. V., Mi, L. - Z., Song, G., and Springer, T. A. (2007) Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. Proc Natl Acad Sci U S A. 104, 15358-63
Chen, X., Randles, L., Shi, K., Tarasov, S. G., Aihara, H., and Walters, K. J. (2016) Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome. Structure. 24, 1257-70
Chen, S., Yang, Z., Wilkinson, A. W., Deshpande, A. J., Sidoli, S., Krajewski, K., Strahl, B. D., Garcia, B. A., Armstrong, S. A., Patel, D. J., and Gozani, O. (2015) The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol Cell. 60, 319-27

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