Publications
(2015) On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker. Protein Eng Des Sel. 28, 491-9
(2015) Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog. Nucleic Acids Res. 43, 11061-7
(2015) Probing the role of sequence in the assembly of three-dimensional DNA crystals. Biopolymers. 103, 618-26
(2015) Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science. 347, 1152-5
(2015) The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol Cell. 60, 319-27
(2014) p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.. Proc Natl Acad Sci U S A. 111, 15946-51
(2014) PFKFB3 regulates oxidative stress homeostasis via its S-glutathionylation in cancer. J Mol Biol. 426, 830-42
(2014) A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Mol Cell. 53, 606-16
(2014) Phosphates in the Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution. Acta Crystallogr D Biol Crystallogr. 70, 1790-800
(2014) Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature. 516, 126-30
(2014) Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proc Natl Acad Sci U S A. 111, 16724-9
(2014) Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam.. Proc Natl Acad Sci U S A. 111, 12769-74
(2014) A protein engineered to bind uranyl selectively and with femtomolar affinity. Nat Chem. 6, 236-41
(2014) A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome. Nat Struct Mol Biol. 21, 787-93
(2013) Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 20, 991-1001
(2013) Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1.. Proc Natl Acad Sci U S A. 110, 19772-7
(2013) Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 498, 385-9
(2013) A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding. PLoS One. 8, e56892
(2013) Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A. 110, 264-9
(2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 22, 585-600
(2012) Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry. 51, 4343-53
(2012) Proline: Mother Nature's cryoprotectant applied to protein crystallography. Acta Crystallogr D Biol Crystallogr. 68, 1010-8
(2012) Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell. 151, 1005-16