Found 921 results
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Mason, E. O., Goldgur, Y., Robev, D., Freywald, A., Nikolov, D. B., and Himanen, J. P. (2021) Structure of the EphB6 receptor ectodomain. PLoS One. 16, e0247335
Cabarca, S., de Souza, M. Frazão, de Oliveira, A. Albert, Muniz, G. S. Vignoli, M Lamy, T., Reis, C. Vinicius D., Takarada, J., Effer, B., Souza, L. Santos, de la Torre, L. Iriarte, Couñago, R., Oliveira, C. Luis Pinto, and Balan, A. (2021) Structure of the PknF and conformational changes induced in forkhead-associated regulatory domains. Curr Res Struct Biol. 3, 165-178
Mann, M. K., Zepeda-Velázquez, C. A., González-Álvarez, H., Dong, A., Kiyota, T., Aman, A. M., Loppnau, P., Li, Y., Wilson, B., Arrowsmith, C. H., Al-awar, R., Harding, R. J., and Schapira, M. (2021) Structure-Activity Relationship of USP5 Inhibitors. J Med Chem. 64, 15017-15036
Hu, D. X., Patel, S., Chen, H., Wang, S., Staben, S. T., Dimitrova, Y. N., Wallweber, H. Ackerly, Lee, J. Y., Chan, G. Ka Yan, Sneeringer, C. J., Prangley, M. S., Moffat, J. G., Wu, K. C., Schutt, L. K., Salphati, L., Pang, J., McNamara, E., Huang, H., Chen, Y., Wang, Y., Zhao, W., Lim, J., Murthy, A., and Siu, M. (2021) Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 10.1021/acs.jmedchem.1c01180
Mieher, J. L., Schormann, N., Wu, R., Patel, M., Purushotham, S., Wu, H., Scoffield, J., and Deivanayagam, C. (2021) Structure-Function Characterization of Streptococcus intermedius Surface Antigen Pas. J Bacteriol. 203, e0017521
Deshmukh, M. G., Ippolito, J. A., Zhang, C. - H., Stone, E. A., Reilly, R. A., Miller, S. J., Jorgensen, W. L., and Anderson, K. S. (2021) Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease. Structure. 10.1016/j.str.2021.06.002
Sharon, I., Haque, A. S., Grogg, M., Lahiri, I., Seebach, D., Leschziner, A. E., Hilvert, D., and T Schmeing, M. (2021) Structures and function of the amino acid polymerase cyanophycin synthetase. Nat Chem Biol. 17, 1101-1110
Liu, D., Shao, Y., Piccirilli, J. A., and Weizmann, Y. (2021) Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution. Sci Adv. 7, eabf4459
Lim, S. Mei, Cruz, V. E., Antoku, S., Gundersen, G. G., and Schwartz, T. U. (2021) Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins. Structure. 10.1016/j.str.2020.12.013
Maciunas, L. J., Porter, N., Lee, P. J., Gupta, K., and Loll, P. J. (2021) Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states. Acta Crystallogr D Struct Biol. 77, 1027-1039
Liew, J. J. M., Saudi, I. M. El, Nguyen, S. V., Wicht, D. K., and Dowling, D. P. (2021) Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer. J Biol Chem. 297, 100823
Su, C. - C., Klenotic, P. A., Cui, M., Lyu, M., Morgan, C. E., and Yu, E. W. (2021) Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport. PLoS Biol. 19, e3001370
Fang, J., Leichter, S. M., Jiang, J., Biswal, M., Lu, J., Zhang, Z. - M., Ren, W., Zhai, J., Cui, Q., Zhong, X., and Song, J. (2021) Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv. 10.1126/sciadv.abd9224
Dubiella, C., Pinch, B. J., Koikawa, K., Zaidman, D., Poon, E., Manz, T. D., Nabet, B., He, S., Resnick, E., Rogel, A., Langer, E. M., Daniel, C. J., Seo, H. - S., Chen, Y., Adelmant, G., Sharifzadeh, S., Ficarro, S. B., Jamin, Y., da Costa, B. Martins, Zimmerman, M. W., Lian, X., Kibe, S., Kozono, S., Doctor, Z. M., Browne, C. M., Yang, A., Stoler-Barak, L., Shah, R. B., Vangos, N. E., Geffken, E. A., Oren, R., Koide, E., Sidi, S., Shulman, Z., Wang, C., Marto, J. A., Dhe-Paganon, S., Look, T., Zhou, X. Zhen, Lu, K. Ping, Sears, R. C., Chesler, L., Gray, N. S., and London, N. (2021) Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 10.1038/s41589-021-00786-7
Mitcheltree, M. J., Pisipati, A., Syroegin, E. A., Silvestre, K. J., Klepacki, D., Mason, J. D., Terwilliger, D. W., Testolin, G., Pote, A. R., J Y Wu, K., Ladley, R. Porter, Chatman, K., Mankin, A. S., Polikanov, Y. S., and Myers, A. G. (2021) A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 10.1038/s41586-021-04045-6
Batool, Z., Lomakin, I. B., Polikanov, Y. S., and Bunick, C. G. (2020) Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 10.1073/pnas.2008671117
Christensen, E. M., Bogner, A. N., Vandekeere, A., Tam, G. S., Patel, S. M., Becker, D. F., Fendt, S. - M., and Tanner, J. J. (2020) Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1. J Biol Chem. 10.1074/jbc.RA120.016106
Liosi, M. - E., Krimmer, S. G., Newton, A. S., Dawson, T., Puleo, D. E., Cutrona, K. J., Suzuki, Y., Schlessinger, J., and Jorgensen, W. L. (2020) Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. J Med Chem. 10.1021/acs.jmedchem.0c00192
Pomerantz, W. Charles Kr, Cui, H., Divakaran, A., Pandey, A. K., Johnson, J. A., Zahid, H., Hoell, Z. J., Ellingson, M. O., Shi, K., Aihara, H., and Harki, D. A. (2020) Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement. Angew Chem Int Ed Engl. 10.1002/anie.202008625
Schuhmacher, M. Kirstin, Beldar, S., Khella, M. S., Bröhm, A., Ludwig, J., Tempel, W., Weirich, S., Min, J., and Jeltsch, A. (2020) Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Commun Biol. 3, 511
Wittenborn, E. C., Guendon, C., Merrouch, M., Benvenuti, M., Fourmond, V., Léger, C., Drennan, C. L., and Dementin, S. (2020) The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance in Ni-Fe Carbon Monoxide Dehydrogenase. ACS Catal. 10, 7328-7335
A Saraswati, P., Relitti, N., Brindisi, M., Osko, J. D., Chemi, G., Federico, S., Grillo, A., Brogi, S., McCabe, N. H., Turkington, R. C., Ibrahim, O., O'Sullivan, J., Lamponi, S., Ghanim, M., Kelly, V. P., Zisterer, D., Amet, R., Barroeta, P. Hannon, Vanni, F., Ulivieri, C., Herp, D., Sarno, F., Di Costanzo, A., Saccoccia, F., Ruberti, G., Jung, M., Altucci, L., Gemma, S., Butini, S., Christianson, D. W., and Campiani, G. (2020) Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation. ACS Med Chem Lett. 11, 2268-2276
Rizzolo, K., Weitz, A. C., Cohen, S. E., Drennan, C. L., Hendrich, M. P., and Elliott, S. J. (2020) A Stable Ferryl Porphyrin at the Active Site of Y463M BthA. J Am Chem Soc. 142, 11978-11982
Morehouse, B. R., Govande, A. A., Millman, A., Keszei, A. F. A., Lowey, B., Ofir, G., Shao, S., Sorek, R., and Kranzusch, P. J. (2020) STING cyclic dinucleotide sensing originated in bacteria. Nature. 10.1038/s41586-020-2719-5
Harvey, C. M., O'Toole, K. H., Liu, C., Mariano, P., Dunaway-Mariano, D., and Allen, K. N. (2020) Structural Analysis of Binding Determinants of Trehalose-6-phosphate Phosphatase Using Ground-State Complexes. Biochemistry. 59, 3247-3257