Publications
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain. ACS Chem Biol. 18, 1200-1207
(2023) The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nat Chem Biol. 10.1038/s41589-021-00931-2
(2021) Fluorogenic aptamers resolve the flexibility of RNA junctions using orientation-dependent FRET. RNA. 27, 433-444
(2021) Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form. Proc Natl Acad Sci U S A. 111, 12775-80
(2014) (2023) Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chem Biol. 5, 701-11
(2010) Functional and Structural Analysis of the Toxin-Binding Site of the Cadherin G-Protein-Coupled Receptor, BT-R, for Cry1A Toxins of . Biochemistry. 61, 752-766
(2022) (2016) Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nat Med. 29, 700-709
(2023) H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.. Nature. 534, 714-718
(2016) H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.. Nature. 534, 714-718
(2016) The HaloTag as a general scaffold for far-red tunable chemigenetic indicators. Nat Chem Biol. 17, 718-723
(2021) The HaloTag as a general scaffold for far-red tunable chemigenetic indicators. Nat Chem Biol. 17, 718-723
(2021) Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. J Med Chem. 64, 9960-9988
(2021) Hatchet ribozyme structure and implications for cleavage mechanism. Proc Natl Acad Sci U S A. 10.1073/pnas.1902413116
(2019) Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep. 34, 108639
(2021) (2014) High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry. 49, 8803-12
(2010) High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding. J Biol Chem. 298, 102454
(2022) (2024) (2024) Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem. 64, 10849-10877
(2021) HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nat Commun. 9, 1111
(2018) HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight. 10.1172/jci.insight.131437
(2020) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat Chem Biol. 13, 1195-1201
(2017)