Staff Publications
Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev. 29, 1326-40 (2015)
Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302. Protein Sci. 24, 1942-55 (2015)
Structural basis for phosphatidylinositol-phosphate biosynthesis. Nat Commun. 6, 8505 (2015)
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase. Mol Biochem Parasitol. 204, 64-76 (2015)
Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis. J Biol Chem. 290, 28559-74 (2015)
Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2. J Biol Chem. 290, 12793-803 (2015)
Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 58, 9498-509 (2015)
X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 524, 252-6 (2015)
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science. 344, 1275-9 (2014)
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 289, 6799-808 (2014)
Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature. 515, 448-52 (2014)
Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis. Cancer Prev Res (Phila). 7, 1056-66 (2014)
Structural basis for the recruitment of glycogen synthase by glycogenin. Proc Natl Acad Sci U S A. 111, E2831-40 (2014)
Crystal structure of the Campylobacter jejuni CmeC outer membrane channel. Protein Sci. 23, 954-61 (2014)
Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis. Acta Crystallogr F Struct Biol Commun. 70, 156-9 (2014)
Structural basis for catalysis in a CDP-alcohol phosphotransferase. Nat Commun. 5, 4068 (2014)
Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis. J Biol Chem. 289, 16526-40 (2014)
In-line alignment and Mg²⁺ coordination at the cleavage site of the env22 twister ribozyme.. Nat Commun. 5, 5534 (2014)
Crystal structure of a eukaryotic group II intron lariat. Nature. 514, 193-7 (2014)
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 5, 4202 (2014)
Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A. 111, 4043-8 (2014)
Weak data do not make a free lunch, only a cheap meal. Acta Crystallogr D Biol Crystallogr. 70, 253-60 (2014)
Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res. 42, 10845-55 (2014)
Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. J Biol Chem. 289, 31905-13 (2014)
Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel. PLoS One. 9, e97475 (2014)
The structure of human 15-lipoxygenase-2 with a substrate mimic. J Biol Chem. 289, 8562-9 (2014)
Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci. 23, 423-32 (2014)
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex. Biochem Biophys Res Commun. 446, 568-73 (2014)
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 344, 1405-10 (2014)
Crystal structure of yeast DNA polymerase ε catalytic domain.. PLoS One. 9, e94835 (2014)
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol Cell. 53, 221-34 (2014)
Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nat Struct Mol Biol. 21, 771-7 (2014)
Structural analysis of base substitutions in Thermus thermophilus 16S rRNA conferring streptomycin resistance. Antimicrob Agents Chemother. 58, 4308-17 (2014)
The sole tryptophan of amicyanin enhances its thermal stability but does not influence the electronic properties of the type 1 copper site. Arch Biochem Biophys. 550-551, 20-7 (2014)
Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump. PLoS One. 9, e97903 (2014)