Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein.
Publication Type:Journal Article
Source:Chem Commun (Camb), Volume 52, Issue 28, p.5041-4 (2016)
Keywords:Bacterial Proteins, Molecular Structure, Nanostructures, Nanotechnology, Protein Engineering, Salmonella typhimurium
<p>We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology.</p>