PILATUS Publications
(2020) The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication. PLoS Pathog. 16, e1008336
(2020) Structure and Function of LCI1: A plasma membrane CO channel in the Chlamydomonas CO concentrating mechanism. Plant J. 10.1111/tpj.14745
(2020) Molecular basis for catabolism of the abundant metabolite -4-hydroxy-L-proline by a microbial glycyl radical enzyme. Elife. 10.7554/eLife.51420
(2020) Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B. FASEB Bioadv. 2, 49-58
(2020) Structural basis of cell surface signaling by a conserved sigma regulator in Gram-negative bacteria. J Biol Chem. 10.1074/jbc.RA119.010697
(2020) Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. Structure. 10.1016/j.str.2020.01.005
(2020) Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nat Chem Biol. 10.1038/s41589-020-0481-5
(2020) Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity. Biochem J. 477, 905-923
(2020) The full-length structure of Thermus scotoductus OLD defines the ATP hydrolysis properties and catalytic mechanism of Class 1 OLD family nucleases. Nucleic Acids Res. 48, 2762-2776
(2020) Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.. Cell Rep. 30, 2655-2671.e7
(2020) Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem. 10.1074/jbc.RA119.011025
(2020) Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 117, 4109-4116
(2020) Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res. 10.1093/nar/gkaa075
(2020) Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res. 10.1093/nar/gkaa024
(2020) The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding. Biosci Rep. 10.1042/BSR20193360
(2020) TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun. 11, 547
(2020) Higher-Order Oligomerization of a Chimeric αβγ Bifunctional Diterpene Synthase with Prenyltransferase and Class II Cyclase Activities is Concentration-Dependent.. J Struct Biol. 10.1016/j.jsb.2020.107463
(2020) Structural basis for ribosome recycling by RRF and tRNA. Nat Struct Mol Biol. 27, 25-32
(2020) Structural insights into the promiscuous DNA binding and broad substrate selectivity of fowlpox virus resolvase. Sci Rep. 10, 393
(2020) Structural Basis of the Substrate Selectivity of Viperin. Biochemistry. 10.1021/acs.biochem.9b00741
(2020) Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J Med Chem. 63, 295-308
(2020) Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2). Biochemistry. 10.1021/acs.biochem.9b00943
(2020) Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol. 16, 7-14
(2020) Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. J Gen Physiol. 10.1085/jgp.201912422
(2019) ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Nat Chem Biol. 15, 1232-1240
(2019) Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. ACS Med Chem Lett. 10, 1648-1654
(2019) Tuning Radical Relay Residues by Proton Management Rescues Protein Electron Hopping. J Am Chem Soc. 141, 17571-17587
(2019) Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature. 575, 545-550
(2019) Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme). J Mol Biol. 10.1016/j.jmb.2019.11.002
(2019) Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Nat Commun. 10, 3475
(2019) Aza-proline effectively mimics l-proline stereochemistry in triple helical collagen. Chem Sci. 10, 6979-6983
(2019) Crystal structure of the Wheat dwarf virus Rep domain. Acta Crystallogr F Struct Biol Commun. 75, 744-749
(2019) Crucial Roles of Two Hydrated Mg Ions in Reaction Catalysis of the Pistol Ribozyme. Angew Chem Int Ed Engl. 10.1002/anie.201912522
(2019) Cooperative DNA binding by proteins through DNA shape complementarity. Nucleic Acids Res. 47, 8874-8887
(2019) Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators. Nat Struct Mol Biol. 26, 1106-1113