Publications

Found 2929 results
2026
Bachochin, M. J., McGuire, K. L., Cook, B. D., Ye, Q., Silletti, S., Corbett, K. D., Komives, E. A., and Herzik, M. A. (2026) An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial import. Structure. 34, 273-283.e6
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Kang, A., Joyce, E., Bera, A. K., Hanikel, N., Salike, S., Krishna, R., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., and Baker, D. (2026) Computational design of metallohydrolases. Nature. 649, 246-253
McNellis, M. E., Del Pino, G. Gonzalez-, Serrano-Jiménez, J. A., Forster, E. R., Stoica, A. Ioana, Heldwein, E. E., and Shen, A. (2026) The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination. PLoS Biol. 24, e3003610
Landry, M. L., Malhotra, S., Beresini, M., Chan, C., Chan, E., de la Cruz, C. C., Endres, N. F., Evangelista, M., Gustafson, A., Hu, D., Hunsaker, T., Hsu, P., Izrayelit, Y., La, H., Larrocha, P. Saenz- Lope, Lian, Q., Merchant, M., Mao, J., Mroue, R., Oh, A., Plise, E., Shao, C., Siu, M., Tran, J. C., Wang, Y., Wang, W., Wei, B., Wong, S., Yen, C. - W., Zhou, Y., Purkey, H. E., Heffron, T. P., and Salphati, L. (2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
Appleby, M. V., Kepa, M. W., Winter, G., McAuley, K. E., and Beale, J. H. (2026) Modelling of radiation damage and beam-induced heating of room-temperature samples at extremely high flux MX beamlines. IUCrJ. 10.1107/S2052252525011224
Meeks, K. R., Mattingly, C. J., Nix, J. C., Chuk, O., Protopopov, M. V., Tarkhanova, O. O., and Tanner, J. J. (2026) Serendipitous Discovery of an Allosteric Inhibitor Binding Groove in the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 1 (PYCR1). Biochem J. 10.1042/BCJ20250278
Bonsor, D. A., Finci, L. I., Potter, J. R., Young, L. C., Wall, V. E., de Salazar, R. Goldstein, Geis, K. R., Stephens, T., Finney, J., Nissley, D. V., McCormick, F., and Simanshu, D. K. (2026) Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors. Nat Commun. 10.1038/s41467-026-68319-1
Adams, J. J., Blazer, L. L., Chung, J., Karimi, M., Davidson, T., Blair, B., Waddle, C., Hokanson, C. A., Bruce, H. A., Singer, A. U., Tombak, E. - M., Gildemann, K., Tamberg, N., Kiiver, K., Ustav, M., Ma, Y., Colombo, L., Huang, L. Jun- Shen, Michnick, S. W., Moe, O. W., and Sidhu, S. S. (2026) Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo. Protein Sci. 35, e70462
2025
Primi, M. C., Tavares, M. T., Hatcher, J. M., Kang, H., Kresina, T. A. C., Chakraborty, S., Leroy, E., Schmoker, A. M., Jeon, H., Weisberg, E. L., Akatsu, T., Griffin, J. D., Scott, D. A., and Eck, M. J. (2025) Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain. Eur J Med Chem. 302, 118274
Maurer, D. P., Vu, M., and Schmidt, A. G. (2025) Antigenic drift expands influenza viral escape pathways from recalled humoral immunity. Immunity. 58, 716-727.e6
Pavelich, I. J., Schureck, M. A., Srinivas, P., Blackburn, T. M., Wang, D., Hoffer, E. D., Boamah, M., Zaldana, K., Onuoha, N., Miles, S. J., Grabowicz, M., C Okafor, D., and Dunham, C. M. (2025) Antitoxin control of optimal transcriptional repression in the atypical HigB-HigA toxin-antitoxin system from Proteus vulgaris. Nucleic Acids Res. 10.1093/nar/gkaf610
Nuthanakanti, A., Korn, M., Levenson-Palmer, R., Wu, Y., Babu, N. Rajesh, Huang, X., Banh, R. S., Belasco, J. G., and Serganov, A. (2025) ApaH decaps NpN-capped RNAs in two alternative orientations. Nat Chem Biol. 10.1038/s41589-025-01991-4
Adams, J. J., Blazer, L. L., Chung, J., Karimi, M., Davidson, T., Bruce, H. A., Singer, A. U., Yang, N., Cardarelli, L., Pot, I., Colombo, L., Huang, L. Jun- Shen, Ma, Y., Michnick, S. W., Moe, O. W., and Sidhu, S. S. (2025) An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo. Protein Sci. 34, e70292
Simanshu, D. K., Xu, R., Stice, J. P., Czyzyk, D. J., Feng, S., Denson, J. - P., Riegler, E., Yang, Y., Zhang, C., Donovan, S., Smith, B. P., Abreu-Blanco, M., Chen, M., Feng, C., Fu, L., Rabara, D., Young, L. C., Dyba, M., Yan, W., Lin, K., Ghorbanpoorvalukolaie, S., Larsen, E. K., Malik, W., Champagne, A., Parker, K., Ju, J. Hyun, Jeknic, S., Esposito, D., Turner, D. M., Lightstone, F. C., Wang, B., Wehn, P. M., Wang, K., Stephen, A. G., Maciag, A. E., Hata, A. N., Sinkevicius, K. W., Nissley, D. V., Wallace, E. M., McCormick, F., and Beltran, P. J. (2025) BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.. Science. 10.1126/science.adq2004
Kröll-Hermi, A., Stoetzel, C., Etard, C., Halabelian, L., Schaefer, E., Scheidecker, S., Kahrizi, K., Payman, J., Geoffroy, V., Prasad, M., Obringer, C., Ruch, L., Girard, A., Zeng, H., Li, F., Plassard, D., Keime, C., Mattioli, F., Feger, C., Piton, A., Fujita, A., Matsumoto, N., Castro, M. Augusto Ar, Ae, K. Chong, Ruaud, L., Levy, J., Dozières, B., Tabet, A. - C., Wentzensen, I. M., Santiago-Sim, T., Yusupov, R., Tveten, K., Smeland, M. Falkenberg, Alkhunaizi, E., Cowing, G., Li, C., Wortmann, S. B., Feichtinger, R. G., Mayr, J. A., Gonorazky, H., Jing, G., Wang, X., Wang, J., Bierhals, T., Grinstein, L., Herget, T., Ruiz, A., Gabau, E., Kampmeier, A., Kassel, O., Kuechler, A., Platzer, K., Jamra, R. Abou, Woerner, A., Idleburg, M., Kircher, S. Gerit, Laccone, F., Golob, B., Peterlin, B., Čuturilo, G., Tasic, V., Kolvenbach, C. M., Hildebrandt, F., Ramos, L. L. P., Kok, F., Buck, C. Barbosa, van de Laar, I. M. B. H., de Man, S. A., Taşdelen, E., Sezer, A., Büke, A., Yavuz, Z., Çomoğlu, S. Selçuk, Costin, C., Them, F. Tran Mau, Lacaze, E., Courtin, T., Héron, D., Keren, B., Whalen, S., Roume, J., Yang, Y., Hoffer, M. J. V., van Haeringen, A., Najmabadi, H., Arrowsmith, C. H., Strähle, U., Dollfus, H., and Muller, J. (2025) Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability. Am J Hum Genet. 10.1016/j.ajhg.2025.10.014
McLaughlin, J. E., Rudolph, M. J., Dutta, A., Li, X. - P., Tsymbal, A. M., Chen, Y., Bhattacharya, S., Algava, B., Goger, M., Roberge, J. Y., and Tumer, N. E. (2025) Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site. J Biol Chem. 10.1016/j.jbc.2025.108310
Alexander, P., Chan, A. H., Rabara, D., Swain, M., Larsen, E. K., Dyba, M., Chertov, O., Ashraf, M., Champagne, A., Lin, K., Maciag, A., Gillette, W. K., Nissley, D. V., McCormick, F., Simanshu, D. K., and Stephen, A. G. (2025) Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints. J Biol Chem. 10.1016/j.jbc.2025.110331
Rodriguez, A. A., Cirulli, A. E., Chau, K., Nguyen, J., Ye, Q., and Corbett, K. D. (2025) Bipartite chromatin recognition by Hop1 from two diverged Holozoa. Life Sci Alliance. 10.26508/lsa.202503428
Jangra, M., Travin, D. Y., Aleksandrova, E. V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B. K., Vázquez-Laslop, N., Polikanov, Y. S., Mankin, A. S., and Wright, G. D. (2025) A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome. Nature. 10.1038/s41586-025-08723-7
Paul, M. E., Chen, D., Vish, K. J., Lartey, N. L., Hughes, E., Freeman, Z. T., Saunders, T. L., Stiegler, A. L., King, P. D., and Boggon, T. J. (2025) The C2 domain augments Ras GTPase-activating protein catalytic activity. Proc Natl Acad Sci U S A. 122, e2418433122
Robles, J. Torres, Stiegler, A. L., Boggon, T. J., and Turk, B. E. (2025) Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions. J Biol Chem. 10.1016/j.jbc.2025.108348
Wein, T., Millman, A., Lange, K., Yirmiya, E., Hadary, R., Garb, J., Melamed, S., Amitai, G., Dym, O., Steinruecke, F., Hill, A. B., Kranzusch, P. J., and Sorek, R. (2025) CARD domains mediate anti-phage defence in bacterial gasdermin systems. Nature. 10.1038/s41586-024-08498-3
Qiu, W., Trinh, T. Kim Hoang, Catalano, C., Mehta, A., Desai, U. R., Kellogg, G. E., Hendrickson, W. A., and Guo, Y. (2025) Cholesterol-dependent enzyme activity of human TSPO1. Proc Natl Acad Sci U S A. 122, e2323045122
Martin, K. N., Lam, G., Reznichenko, O., Brunner, K. E., Zdilla, M. J., McCarthy, S. E., Granzhan, A., and Yatsunyk, L. A. (2025) Conformational Change in a Four-Tetrad DNA G-Quadruplex upon Intercalation of a Small-Molecule Ligand PyDH2. Angew Chem Int Ed Engl. 64, e202501443
Justen, S. F., Fenwick, M. K., Axt, K. K., Cherry, J. A., Ealick, S. E., and Philmus, B. (2025) Crystal Structure, Modeling, and Identification of Key Residues Provide Insights into the Mechanism of the Key Toxoflavin Biosynthesis Protein ToxD. Biochemistry. 10.1021/acs.biochem.4c00421

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