Publications

Found 858 results
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2025
DeAngelo, T. M., Adhikary, U., Korshavn, K. J., Seo, H. - S., Brotzen-Smith, C. R., Camara, C. M., Dhe-Paganon, S., Bird, G. H., Wales, T. E., and Walensky, L. D. (2025) Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices. Nat Commun. 16, 8623
Syroegin, E. A., Aleksandrova, E. V., Kruglov, A. A., Paranjpe, M. N., Svetlov, M. S., and Polikanov, Y. S. (2025) Structural insights into context-specific inhibition of bacterial translation by macrolides. Nat Commun. 16, 9685
Misra, A., Rahisuddin, R., Parihar, M., Arya, S., Viswanathan, T., Jackson, N., Qi, S., Chan, S. - H., Harris, R. S., Martinez-Sobrido, L., and Gupta, Y. K. (2025) Structural insights into the assembly and regulation of 2'-O RNA methylation by SARS-CoV-2 nsp16/nsp10. Structure. 33, 1027-1039.e4
Yirmiya, E., Hobbs, S. J., Leavitt, A., Osterman, I., Avraham, C., Hochhauser, D., Madhala, B., Skovorodka, M., Tan, J. M. J., Toyoda, H. C., Chebotar, I., Itkin, M., Malitsky, S., Amitai, G., Kranzusch, P. J., and Sorek, R. (2025) Structure-guided discovery of viral proteins that inhibit host immunity. Cell. 10.1016/j.cell.2024.12.035
Yirmiya, E., Hobbs, S. J., Leavitt, A., Osterman, I., Avraham, C., Hochhauser, D., Madhala, B., Skovorodka, M., Tan, J. M. J., Toyoda, H. C., Chebotar, I., Itkin, M., Malitsky, S., Amitai, G., Kranzusch, P. J., and Sorek, R. (2025) Structure-guided discovery of viral proteins that inhibit host immunity. Cell. 10.1016/j.cell.2024.12.035
Adams, J. J., Bruce, H. A., Subramania, S., Ploder, L., Garcia, J., Pot, I., Blazer, L. L., Singer, A. U., and Sidhu, S. S. (2025) Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation. Protein Sci. 34, e70145
Ackloo, S., Li, F., Szewczyk, M., Seitova, A., Loppnau, P., Zeng, H., Xu, J., Ahmad, S., Arnautova, Y. A., Baghaie, A. J., Beldar, S., Bolotokova, A., Centrella, P. A., Chau, I., Clark, M. A., Cuozzo, J. W., Dehghani-Tafti, S., Disch, J. S., Dong, A., Dumas, A., Feng, J. A., Ghiabi, P., Gibson, E., Gilmer, J., Goldman, B., Green, S. R., Guié, M. - A., Guilinger, J. P., Harms, N., Herasymenko, O., Houliston, S., Hutchinson, A., Kearnes, S., Keefe, A. D., Kimani, S. W., Kramer, T., Kutera, M., Kwak, H. A., Lento, C., Li, Y., Liu, J., Loup, J., Machado, R. A. C., Mulhern, C. J., Perveen, S., Righetto, G. L., Riley, P., Shrestha, S., Sigel, E. A., Silva, M., Sintchak, M. D., Slakman, B. L., Taylor, R. D., Thompson, J., Torng, W., Underkoffler, C., von Rechenberg, M., Walsh, R. T., Watson, I., Wilson, D. J., Wolf, E., Yadav, M., Yazdi, A. K., Zhang, J., Zhang, Y., Santhakumar, V., Edwards, A. M., Barsyte-Lovejoy, D., Schapira, M., Brown, P. J., Halabelian, L., and Arrowsmith, C. H. (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
Ackloo, S., Li, F., Szewczyk, M., Seitova, A., Loppnau, P., Zeng, H., Xu, J., Ahmad, S., Arnautova, Y. A., Baghaie, A. J., Beldar, S., Bolotokova, A., Centrella, P. A., Chau, I., Clark, M. A., Cuozzo, J. W., Dehghani-Tafti, S., Disch, J. S., Dong, A., Dumas, A., Feng, J. A., Ghiabi, P., Gibson, E., Gilmer, J., Goldman, B., Green, S. R., Guié, M. - A., Guilinger, J. P., Harms, N., Herasymenko, O., Houliston, S., Hutchinson, A., Kearnes, S., Keefe, A. D., Kimani, S. W., Kramer, T., Kutera, M., Kwak, H. A., Lento, C., Li, Y., Liu, J., Loup, J., Machado, R. A. C., Mulhern, C. J., Perveen, S., Righetto, G. L., Riley, P., Shrestha, S., Sigel, E. A., Silva, M., Sintchak, M. D., Slakman, B. L., Taylor, R. D., Thompson, J., Torng, W., Underkoffler, C., von Rechenberg, M., Walsh, R. T., Watson, I., Wilson, D. J., Wolf, E., Yadav, M., Yazdi, A. K., Zhang, J., Zhang, Y., Santhakumar, V., Edwards, A. M., Barsyte-Lovejoy, D., Schapira, M., Brown, P. J., Halabelian, L., and Arrowsmith, C. H. (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
Ackloo, S., Li, F., Szewczyk, M., Seitova, A., Loppnau, P., Zeng, H., Xu, J., Ahmad, S., Arnautova, Y. A., Baghaie, A. J., Beldar, S., Bolotokova, A., Centrella, P. A., Chau, I., Clark, M. A., Cuozzo, J. W., Dehghani-Tafti, S., Disch, J. S., Dong, A., Dumas, A., Feng, J. A., Ghiabi, P., Gibson, E., Gilmer, J., Goldman, B., Green, S. R., Guié, M. - A., Guilinger, J. P., Harms, N., Herasymenko, O., Houliston, S., Hutchinson, A., Kearnes, S., Keefe, A. D., Kimani, S. W., Kramer, T., Kutera, M., Kwak, H. A., Lento, C., Li, Y., Liu, J., Loup, J., Machado, R. A. C., Mulhern, C. J., Perveen, S., Righetto, G. L., Riley, P., Shrestha, S., Sigel, E. A., Silva, M., Sintchak, M. D., Slakman, B. L., Taylor, R. D., Thompson, J., Torng, W., Underkoffler, C., von Rechenberg, M., Walsh, R. T., Watson, I., Wilson, D. J., Wolf, E., Yadav, M., Yazdi, A. K., Zhang, J., Zhang, Y., Santhakumar, V., Edwards, A. M., Barsyte-Lovejoy, D., Schapira, M., Brown, P. J., Halabelian, L., and Arrowsmith, C. H. (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
Ackloo, S., Li, F., Szewczyk, M., Seitova, A., Loppnau, P., Zeng, H., Xu, J., Ahmad, S., Arnautova, Y. A., Baghaie, A. J., Beldar, S., Bolotokova, A., Centrella, P. A., Chau, I., Clark, M. A., Cuozzo, J. W., Dehghani-Tafti, S., Disch, J. S., Dong, A., Dumas, A., Feng, J. A., Ghiabi, P., Gibson, E., Gilmer, J., Goldman, B., Green, S. R., Guié, M. - A., Guilinger, J. P., Harms, N., Herasymenko, O., Houliston, S., Hutchinson, A., Kearnes, S., Keefe, A. D., Kimani, S. W., Kramer, T., Kutera, M., Kwak, H. A., Lento, C., Li, Y., Liu, J., Loup, J., Machado, R. A. C., Mulhern, C. J., Perveen, S., Righetto, G. L., Riley, P., Shrestha, S., Sigel, E. A., Silva, M., Sintchak, M. D., Slakman, B. L., Taylor, R. D., Thompson, J., Torng, W., Underkoffler, C., von Rechenberg, M., Walsh, R. T., Watson, I., Wilson, D. J., Wolf, E., Yadav, M., Yazdi, A. K., Zhang, J., Zhang, Y., Santhakumar, V., Edwards, A. M., Barsyte-Lovejoy, D., Schapira, M., Brown, P. J., Halabelian, L., and Arrowsmith, C. H. (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
Tang, J., Moorthy, R., Hirsch, L. E., Demir, Ö., Baker, Z. D., Naumann, J. A., Jones, K. F. M., Grillo, M. J., Haefner, E. S., Shi, K., Levy, M. J., Gupta, H. B., Aihara, H., Harris, R. S., Amaro, R. E., Levinson, N. M., and Harki, D. A. (2025) Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 32, 352-362.e10
Tang, J., Moorthy, R., Hirsch, L. E., Demir, Ö., Baker, Z. D., Naumann, J. A., Jones, K. F. M., Grillo, M. J., Haefner, E. S., Shi, K., Levy, M. J., Gupta, H. B., Aihara, H., Harris, R. S., Amaro, R. E., Levinson, N. M., and Harki, D. A. (2025) Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 32, 352-362.e10
Liu, B. Hui, Liu, M., Radhakrishnan, S., Dai, M. - Y., Jaladanki, C. Kumar, Gao, C., Tang, J. Ping, Kumari, K., Go, M. Lin, Vu, K. Anh L., Kwon, J., Seo, H. - S., Song, K., Tian, X., Feng, L., Tan, J. L., Melkonian, A. V., Liu, Z., Wulf, G., Arthanari, H., Qi, J., Dhe-Paganon, S., Clohessy, J. G., Choong, Y. Khai, Sivaraman, J., Fan, H., Tenen, D. G., and Chai, L. (2025) Targeting transcription factors through an IMiD independent zinc finger domain. EMBO Mol Med. 17, 1393-1416
Sabonis, D., Avraham, C., Chang, R. B., Lu, A., Herbst, E., Silanskas, A., Vilutis, D., Leavitt, A., Yirmiya, E., Toyoda, H. C., Ruksenaite, A., Zaremba, M., Osterman, I., Amitai, G., Kranzusch, P. J., Sorek, R., and Tamulaitiene, G. (2025) TIR domains produce histidine-ADPR as an immune signal in bacteria. Nature. 642, 467-473
Sabonis, D., Avraham, C., Chang, R. B., Lu, A., Herbst, E., Silanskas, A., Vilutis, D., Leavitt, A., Yirmiya, E., Toyoda, H. C., Ruksenaite, A., Zaremba, M., Osterman, I., Amitai, G., Kranzusch, P. J., Sorek, R., and Tamulaitiene, G. (2025) TIR domains produce histidine-ADPR as an immune signal in bacteria. Nature. 642, 467-473
Kubeš, J., Karabanovich, G., Cong, A. T. Q., Melnikova, I., Lenčová, O., Kollárová, P., Piskáčková, H. Bavlovič, Keresteš, V., Applová, L., Arrouye, L. C. M., Alvey, J. R., Paluncic, J., Witter, T. L., Jirkovská, A., Kuneš, J., Štěrbová-Kovaříková, P., Austin, C. A., Štěrba, M., Šimůnek, T., Roh, J., and Schellenberg, M. J. (2025) Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection. Nat Commun. 16, 4928
Kubeš, J., Karabanovich, G., Cong, A. T. Q., Melnikova, I., Lenčová, O., Kollárová, P., Piskáčková, H. Bavlovič, Keresteš, V., Applová, L., Arrouye, L. C. M., Alvey, J. R., Paluncic, J., Witter, T. L., Jirkovská, A., Kuneš, J., Štěrbová-Kovaříková, P., Austin, C. A., Štěrba, M., Šimůnek, T., Roh, J., and Schellenberg, M. J. (2025) Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection. Nat Commun. 16, 4928
Kubeš, J., Karabanovich, G., Cong, A. T. Q., Melnikova, I., Lenčová, O., Kollárová, P., Piskáčková, H. Bavlovič, Keresteš, V., Applová, L., Arrouye, L. C. M., Alvey, J. R., Paluncic, J., Witter, T. L., Jirkovská, A., Kuneš, J., Štěrbová-Kovaříková, P., Austin, C. A., Štěrba, M., Šimůnek, T., Roh, J., and Schellenberg, M. J. (2025) Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection. Nat Commun. 16, 4928
Kubeš, J., Karabanovich, G., Cong, A. T. Q., Melnikova, I., Lenčová, O., Kollárová, P., Piskáčková, H. Bavlovič, Keresteš, V., Applová, L., Arrouye, L. C. M., Alvey, J. R., Paluncic, J., Witter, T. L., Jirkovská, A., Kuneš, J., Štěrbová-Kovaříková, P., Austin, C. A., Štěrba, M., Šimůnek, T., Roh, J., and Schellenberg, M. J. (2025) Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection. Nat Commun. 16, 4928
J Y Wu, K., Aleksandrova, E. V., Robinson, P. J., Benedetto, A. E., Yu, M., Tresco, B. I. C., N Y See, D., Jiang, T., Ramkissoon, A., Dunand, C. F., Svetlov, M. S., Lee, J., Polikanov, Y. S., and Myers, A. G. (2025) Why Sulfur is Important in Lincosamide Antibiotics. Chem. 10.1016/j.chempr.2025.102480
2024
Rechkoblit, O., Sciaky, D., Kreitler, D. F., Buku, A., Kottur, J., and Aggarwal, A. K. (2024) Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nat Struct Mol Biol. 10.1038/s41594-024-01220-x
Mealka, M., Sierra, N. A., Matteo, D. Avellaneda, Albekioni, E., Khoury, R., Mai, T., Conley, B. M., Coleman, N. J., Sabo, K. A., Komives, E. A., Bobkov, A. A., Cooksy, A. L., Silletti, S., Schiffer, J. M., Huxford, T., and Sohl, C. D. (2024) Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun. 15, 3785
Huang, W., Baliga, C., Aleksandrova, E. V., Atkinson, G., Polikanov, Y. S., Vázquez-Laslop, N., and Mankin, A. S. (2024) Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects. EMBO Rep. 25, 5194-5211
Huang, W., Baliga, C., Aleksandrova, E. V., Atkinson, G., Polikanov, Y. S., Vázquez-Laslop, N., and Mankin, A. S. (2024) Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects. EMBO Rep. 25, 5194-5211
Miller, J. E., Agdanowski, M. P., Dolinsky, J. L., Sawaya, M. R., Cascio, D., Rodriguez, J. A., and Yeates, T. O. (2024) AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. Acta Crystallogr D Struct Biol. 80, 270-278

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