Publications
(2012) Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry. 51, 9234-44
(2012) Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet. 44, 1006-14
(2012) The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell. 151, 267-77
(2012) Identification of the NAD(P)H binding site of eukaryotic UDP-galactopyranose mutase. J Am Chem Soc. 134, 18132-8
(2012) INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis. Proc Natl Acad Sci U S A. 109, 8374-81
(2012) A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. J Am Chem Soc. 134, 10698-705
(2012) A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. J Am Chem Soc. 134, 10698-705
(2012) Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.. Proc Natl Acad Sci U S A. 109, 20913-8
(2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 22, 585-600
(2012) Pseudouridine monophosphate glycosidase: a new glycosidase mechanism. Biochemistry. 51, 9245-55
(2012) Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation. Protein Sci. 21, 26-37
(2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 488, 404-8
(2012) Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc Natl Acad Sci U S A. 109, 15235-40
(2012) Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc Natl Acad Sci U S A. 109, 15235-40
(2012) Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue. Biochemistry. 51, 1476-85
(2012) Structural basis of the substrate specificity of Bacillus cereus adenosine phosphorylase. Acta Crystallogr D Biol Crystallogr. 68, 239-48
(2012) Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 109, 11194-9
(2012) Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation. J Biol Chem. 287, 22377-86
(2012) Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6. Proc Natl Acad Sci U S A. 109, E3424-33
(2012) Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol. 19, 212-9
(2012) Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate. J Am Chem Soc. 134, 9157-9
(2012) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol. 19, 855-65
(2011) Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine. Protein Sci. 20, 1836-44
(2011) Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics.. J Am Chem Soc. 133, 6736-44
(2011) Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase. J Mol Biol. 410, 447-60