Publications

Found 1642 results
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2022
Hobbs, S. J., Wein, T., Lu, A., Morehouse, B. R., Schnabel, J., Leavitt, A., Yirmiya, E., Sorek, R., and Kranzusch, P. J. (2022) Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 10.1038/s41586-022-04716-y
Hobbs, S. J., Wein, T., Lu, A., Morehouse, B. R., Schnabel, J., Leavitt, A., Yirmiya, E., Sorek, R., and Kranzusch, P. J. (2022) Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 10.1038/s41586-022-04716-y
Reglero, C., Dieck, C. L., Zask, A., Forouhar, F., Laurent, A. P., Lin, W. - H. W., Albero, R., Miller, H. I., Ma, C., Gastier-Foster, J. M., Loh, M. L., Tong, L., Stockwell, B. R., Palomero, T., and Ferrando, A. A. (2022) Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discov. 10.1158/2159-8290.CD-22-0010
Reglero, C., Dieck, C. L., Zask, A., Forouhar, F., Laurent, A. P., Lin, W. - H. W., Albero, R., Miller, H. I., Ma, C., Gastier-Foster, J. M., Loh, M. L., Tong, L., Stockwell, B. R., Palomero, T., and Ferrando, A. A. (2022) Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discov. 10.1158/2159-8290.CD-22-0010
Reglero, C., Dieck, C. L., Zask, A., Forouhar, F., Laurent, A. P., Lin, W. - H. W., Albero, R., Miller, H. I., Ma, C., Gastier-Foster, J. M., Loh, M. L., Tong, L., Stockwell, B. R., Palomero, T., and Ferrando, A. A. (2022) Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discov. 10.1158/2159-8290.CD-22-0010
Zuk, A., Si, Z., Loi, S., Bommegowda, S., Hoivik, D., Danthi, S., Molnar, G., Csizmadia, V., and Rabinowitz, M. (2022) Preclinical characterization of vadadustat (AKB-6548), an oral small molecule hypoxia inducible factor prolyl-4-hydroxylase inhibitor, for the potential treatment of renal anemia. J Pharmacol Exp Ther. 10.1124/jpet.122.001126
Lam, K. - H., Tremblay, J. M., Perry, K., Ichtchenko, K., Shoemaker, C. B., and Jin, R. (2022) Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. PLoS Pathog. 18, e1010169
Arrigoni, C., Lolicato, M., Shaya, D., Rohaim, A., Findeisen, F., Fong, L. - K., Colleran, C. M., Dominik, P., Kim, S. S., Schuermann, J. P., DeGrado, W. F., Grabe, M., Kossiakoff, A. A., and Minor, D. L. (2022) Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 29, 537-548
Gero, T. W., Heppner, D. E., Beyett, T. S., To, C., Azevedo, S. C., Jang, J., Bunnell, T., Feru, F., Li, Z., Shin, B. Hee, Soroko, K. M., Gokhale, P. C., Gray, N. S., Jänne, P. A., Eck, M. J., and Scott, D. A. (2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 10.1016/j.bmcl.2022.128718
Hauser, B. M., Sangesland, M., St Denis, K. J., Lam, E. C., Case, J. Brett, Windsor, I. W., Feldman, J., Caradonna, T. M., Kannegieter, T., Diamond, M. S., Balazs, A. B., Lingwood, D., and Schmidt, A. G. (2022) Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting. Cell Rep. 38, 110561
Hauser, B. M., Sangesland, M., St Denis, K. J., Lam, E. C., Case, J. Brett, Windsor, I. W., Feldman, J., Caradonna, T. M., Kannegieter, T., Diamond, M. S., Balazs, A. B., Lingwood, D., and Schmidt, A. G. (2022) Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting. Cell Rep. 38, 110561
Johnson, C. W., Seo, H. - S., Terrell, E. M., Yang, M. - H., KleinJan, F., Gebregiworgis, T., Gasmi-Seabrook, G. M. C., Geffken, E. A., Lakhani, J., Song, K., Bashyal, P., Popow, O., Paulo, J. A., Liu, A., Mattos, C., Marshall, C. B., Ikura, M., Morrison, D. K., Dhe-Paganon, S., and Haigis, K. M. (2022) Regulation of GTPase function by autophosphorylation. Mol Cell. 82, 950-968.e14
Johnson, C. W., Seo, H. - S., Terrell, E. M., Yang, M. - H., KleinJan, F., Gebregiworgis, T., Gasmi-Seabrook, G. M. C., Geffken, E. A., Lakhani, J., Song, K., Bashyal, P., Popow, O., Paulo, J. A., Liu, A., Mattos, C., Marshall, C. B., Ikura, M., Morrison, D. K., Dhe-Paganon, S., and Haigis, K. M. (2022) Regulation of GTPase function by autophosphorylation. Mol Cell. 82, 950-968.e14
Zeller, M. J., Favorov, O., Li, K., Nuthanakanti, A., Hussein, D., Michaud, A., Lafontaine, D. A., Busan, S., Serganov, A., Aubé, J., and Weeks, K. M. (2022) SHAPE-enabled fragment-based ligand discovery for RNA. Proc Natl Acad Sci U S A. 119, e2122660119
Zeller, M. J., Favorov, O., Li, K., Nuthanakanti, A., Hussein, D., Michaud, A., Lafontaine, D. A., Busan, S., Serganov, A., Aubé, J., and Weeks, K. M. (2022) SHAPE-enabled fragment-based ligand discovery for RNA. Proc Natl Acad Sci U S A. 119, e2122660119
Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K. Joshua, Zhang, M., Zhao, D. Yanling, Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P. J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M. T., Greenblatt, J. F., and Min, J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K. Joshua, Zhang, M., Zhao, D. Yanling, Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P. J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M. T., Greenblatt, J. F., and Min, J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K. Joshua, Zhang, M., Zhao, D. Yanling, Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P. J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M. T., Greenblatt, J. F., and Min, J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
Liu, H., Forouhar, F., Lin, A. J., Wang, Q., Polychronidou, V., Soni, R. Kumar, Xia, X., and Stockwell, B. R. (2022) Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol. 10.1016/j.chembiol.2022.11.003
Liu, H., Forouhar, F., Lin, A. J., Wang, Q., Polychronidou, V., Soni, R. Kumar, Xia, X., and Stockwell, B. R. (2022) Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol. 10.1016/j.chembiol.2022.11.003
Vance, T. D. R., Yip, P., Jiménez, E., Li, S., Gawol, D., Byrnes, J., Usón, I., Ziyyat, A., and Lee, J. E. (2022) SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins. Commun Biol. 5, 984
Vance, T. D. R., Yip, P., Jiménez, E., Li, S., Gawol, D., Byrnes, J., Usón, I., Ziyyat, A., and Lee, J. E. (2022) SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins. Commun Biol. 5, 984
Adlakha, J., Hong, Z., Li, P. Q., and Reinisch, K. M. (2022) Structural and biochemical insights into lipid transport by VPS13 proteins. J Cell Biol. 10.1083/jcb.202202030
Baranovskiy, A. G., Babayeva, N. D., Lisova, A. E., Morstadt, L. M., and Tahirov, T. H. (2022) Structural and functional insight into mismatch extension by human DNA polymerase α.. Proc Natl Acad Sci U S A. 119, e2111744119
Prew, M. S., Camara, C. M., Botzanowski, T., Moroco, J. A., Bloch, N. B., Levy, H. R., Seo, H. - S., Dhe-Paganon, S., Bird, G. H., Herce, H. D., Gygi, M. A., Escudero, S., Wales, T. E., Engen, J. R., and Walensky, L. D. (2022) Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun. 13, 3669

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