Publications
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(2018) Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic Acids Res. 10.1093/nar/gky827
(2018) Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. PLoS One. 13, e0202134
(2018) Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem. 10.1074/jbc.M117.802058
(2018) Effects of rigidity on the selectivity of protein kinase inhibitors. Eur J Med Chem. 146, 519-528
(2018) Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.. J Biol Chem. 10.1074/jbc.RA117.000656
(2018) The Eponymous Cofactors in Cytochrome P460s from Ammonia-Oxidizing Bacteria Are Iron Porphyrinoids Whose Macrocycles Are Dibasic. Biochemistry. 57, 334-343
(2018) Exploring local solvation environments of a heme protein using the spectroscopic reporter 4-cyano-l-phenylalanine. RSC Adv. 8, 13503-13512
(2018) Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla. Methods Enzymol. 605, 33-49
(2018) Fatty acyl recognition and transfer by an integral membrane S-acyltransferase. Science. 10.1126/science.aao6326
(2018) Gating mechanisms of acid-sensing ion channels. Nature. 10.1038/nature25782
(2018) Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells.. Sci Immunol. 10.1126/sciimmunol.aav4036
(2018) GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Nat Struct Mol Biol. 10.1038/s41594-018-0031-y
(2018) Glucan Binding Protein C of Mediates both Sucrose-Independent and Sucrose-Dependent Adherence. Infect Immun. 10.1128/IAI.00146-18
(2018) Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. EMBO J. 37, 75-88
(2018) HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease.. Nat Commun. 9, 3359
(2018) High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun. 74, 717-724
(2018) Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J Med Chem. 10.1021/acs.jmedchem.8b01013
(2018) HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nat Commun. 9, 1111
(2018) Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light chain amyloidosis. J Biol Chem. 10.1074/jbc.RA118.004142
(2018) Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Mol Ther. 10.1016/j.ymthe.2018.12.010
(2018) Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.. Nat Chem. 10.1038/s41557-018-0147-z
(2018) Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. PLoS One. 13, e0195048
(2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 10.1093/hmg/ddy128