Publications

Found 4 results
Filters: Author is Roberge, Jacques Y  [Clear All Filters]
2024
Rudolph, M. J., Tsymbal, A. M., Dutta, A., Davis, S. A., Algava, B., Roberge, J. Y., Tumer, N. E., and Li, X. - P. (2024) Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2. ACS Infect Dis. 10.1021/acsinfecdis.4c00224
Gilleran, J. A., Ashraf, K., Delvillar, M., Eck, T., Fondekar, R., Miller, E. B., Hutchinson, A., Dong, A., Seitova, A., De Souza, M. Laureano, Augeri, D., Halabelian, L., Siekierka, J., Rotella, D. P., Gordon, J., Childers, W. E., Grier, M. C., Staker, B. L., Roberge, J. Y., and Bhanot, P. (2024) Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J Med Chem. 67, 3467-3503
Rudolph, M. J., Dutta, A., Tsymbal, A. M., McLaughlin, J. E., Chen, Y., Davis, S. A., Theodorous, S. A., Pierce, M., Algava, B., Zhang, X., Szekely, Z., Roberge, J. Y., Li, X. - P., and Tumer, N. E. (2024) Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin. Bioorg Med Chem. 100, 117614
2025
McLaughlin, J. E., Rudolph, M. J., Dutta, A., Li, X. - P., Tsymbal, A. M., Chen, Y., Bhattacharya, S., Algava, B., Goger, M., Roberge, J. Y., and Tumer, N. E. (2025) Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site. J Biol Chem. 10.1016/j.jbc.2025.108310