Publications

Found 5 results
Filters: Author is Cochrane, C Skyler  [Clear All Filters]
2024
Ennis, A. F., C Cochrane, S., Dome, P. A., Jeong, P., Yu, J., Lee, H., Williams, C. S., Ha, Y., Yang, W., Zhou, P., and Hong, J. (2024) Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales. JACS Au. 4, 4383-4393
2023
Kwak, S. - H., C Cochrane, S., Cho, J., Dome, P. A., Ennis, A. F., Kim, J. Hyun, Zhou, P., and Hong, J. (2023) Development of LpxH inhibitors chelating the active site di-manganese metal cluster of LpxH. ChemMedChem. 10.1002/cmdc.202300023
Zhao, J., C Cochrane, S., Najeeb, J., Gooden, D., Sciandra, C., Fan, P., Lemaitre, N., Newns, K., Nicholas, R. A., Guan, Z., Thaden, J. T., Fowler, V. G., Spasojevic, I., Sebbane, F., Toone, E. J., Duncan, C., Gammans, R., and Zhou, P. (2023) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med. 15, eadf5668
2020
Cho, J., Lee, M., C Cochrane, S., Webster, C. G., Fenton, B. A., Zhao, J., Hong, J., and Zhou, P. (2020) Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 117, 4109-4116
Kwak, S. - H., C Cochrane, S., Ennis, A. F., Lim, W. Young, Webster, C. G., Cho, J., Fenton, B. A., Zhou, P., and Hong, J. (2020) Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors. Bioorg Chem. 102, 104055