At the Plenary Session for the APS/CNM User Meeting, it was announced that the storage ring installation period of the Advanced Photon Source Upgrade project is now scheduled to begin April 17, 2023. NE-CAT and the APS will be 'dark' for 1 year following this date.
Work by the lab of Song Tan at the University of Pennsylvania on structure of the histone demethylase LSD1 bound to its nucleosome substrate together with its accessory protein known as CoREST has been featured on the APS Website.
Malcolm Capel and Frank Murphy will be speaking at "Current and Future Trends in Macromolecular Crystallography Experiments." This workshop is hosted by NSLS-II and will be held virtually March 16-18, 2021. The workshop will be from 12pm - 6pm EST each day.
Malcolm will be speaking in Session I (March 16, 2021). His talk is entitled, "New endstations at NE-CAT: MD3UP microdiffractometer and 30 puck ALS-style loader."
Structural work on SARS-CoV-2 papain-like protease, SARS-CoV-2-PLpro, required for processing viral polyproteins to generate a functional replicase complex and enable viral spread has been featured as a highlight on the APS website.
Work on SARS-CoV-2 RNA capping by the lab of Yogesh Gupta using NE-CAT and previously published at BioRxiv has now been published at Nature Communications, featured on the Science Board website and is also a highlight on the APS website
SARS-CoV-2 is a zoonotic virus that has caused a pandemic of severe respiratory disease—COVID-19— within several months of its initial identification. Comparable to the first SARS-CoV, this novel coronavirus’s surface Spike (S) glycoprotein mediates cell entry via the human ACE-2 receptor, and, thus, is the principal target for the development of vaccines and immunotherapeutics.
Per the Illinois Stay-At-Home Order, NE-CAT has only has available beamtime for COVID-19 related research. On-site access is not available and all data collection must be conducted remotely.
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