Publications
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D. J Med Chem. 10.1021/acs.jmedchem.1c00141 (2021)
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 10.1021/acs.jmedchem.1c00279 (2021)
Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep. 35, 109206 (2021)
Structural Basis for the Stereospecific Inhibition of the Dual Proline/Hydroxyproline Catabolic Enzyme ALDH4A1 by Trans-4-Hydroxy-L-Proline. Protein Sci. 10.1002/pro.4131 (2021)
Structural basis for the initiation of COPII vesicle biogenesis. Structure. 10.1016/j.str.2021.03.013 (2021)
The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from : A Structural Insight. Biochemistry. 60, 1564-1568 (2021)
Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome. Antibiotics (Basel). 10.3390/antibiotics10040390 (2021)
A useful epitope tag derived from maltose binding protein. Protein Sci. 10.1002/pro.4088 (2021)
Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J Am Chem Soc. 143, 6865-6876 (2021)
Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome. Commun Biol. 4, 249 (2021)
Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 (ARH3) reveals the basis of metal selectivity and different roles for the two Mg ions. J Biol Chem. 10.1016/j.jbc.2021.100692 (2021)
Design of multi-scale protein complexes by hierarchical building block fusion. Nat Commun. 12, 2294 (2021)
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex. Genes Dev. 35, 392-409 (2021)
Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex. Proc Natl Acad Sci U S A. 10.1073/pnas.2020393118 (2021)
Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations. ACS Cent Sci. 7, 467-475 (2021)
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nat Commun. 12, 2016 (2021)
The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site. Biochemistry. 10.1021/acs.biochem.1c00152 (2021)
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase. Cell Chem Biol. 10.1016/j.chembiol.2021.03.001 (2021)
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 10.1101/2021.03.05.434000 (2021)
Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands. J Lipid Res. 10.1016/j.jlr.2021.100054 (2021)
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Mol Cell. 81, 739-755.e7 (2021)
Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J Biol Chem. 10.1016/j.jbc.2021.100492 (2021)
Structure of 3'-PO/5'-OH RNA ligase RtcB in complex with a 5'-OH oligonucleotide. RNA. 10.1261/rna.078692.121 (2021)
Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead. ACS Med Chem Lett. 12, 249-255 (2021)
Phospho-dependent signaling during the general stress response by the atypical response regulator and ClpXP adaptor RssB. Protein Sci. 10.1002/pro.4047 (2021)
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun. 12, 1176 (2021)
De novo design of transmembrane β barrels.. Science. 10.1126/science.abc8182 (2021)
Molecular basis for ubiquitin ligase CRL2-mediated recognition of C-degron. Nat Chem Biol. 10.1038/s41589-020-00703-4 (2021)
Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J Am Chem Soc. 143, 623-627 (2021)
SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 10.1101/2020.11.13.381533 (2021)
Barium blockade of the KcsA channel in open and closed conformation datasets. Data Brief. 32, 106135 (2020)
Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1. Structure. 28, 29-43.e6 (2020)
Discovery of an ultra-specific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway. J Biol Chem. 10.1074/jbc.RA120.015631 (2020)
Redox priming promotes Aurora A activation during mitosis. Sci Signal. 10.1126/scisignal.abb6707 (2020)
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.. Cell Rep. 32, 107922 (2020)