Publications
Open and Closed Structures of a Barium-Blocked Potassium Channel. J Mol Biol. 10.1016/j.jmb.2020.06.012 (2020)
Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. RNA. 10.1261/rna.075879.120 (2020)
Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proc Natl Acad Sci U S A. 117, 16333-16338 (2020)
The Heme-Lys Cross-Link in Cytochrome P460 Promotes Catalysis by Enforcing Secondary Coordination Sphere Architecture. Biochemistry. 59, 2289-2298 (2020)
CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 182, 38-49.e17 (2020)
Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. bioRxiv. 10.1101/2020.05.17.100685 (2020)
Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. 53, 106-114.e5 (2020)
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 10.1074/jbc.RA120.013638 (2020)
internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J Biol Chem. 10.1074/jbc.RA119.011080 (2020)
HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight. 10.1172/jci.insight.131437 (2020)
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate. Mol Cell. 10.1016/j.molcel.2020.04.019 (2020)
Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator. J Biol Chem. 10.1074/jbc.RA120.013264 (2020)
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. J Med Chem. 10.1021/acs.jmedchem.0c00192 (2020)
Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight. Sci Adv. 6, eaay8937 (2020)
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 11, 1067 (2020)
Structural basis of receptor recognition by SARS-CoV-2. Nature. 10.1038/s41586-020-2179-y (2020)
Molecular basis for hycanthone drug action in schistosome parasites. Mol Biochem Parasitol. 236, 111257 (2020)
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med. 26, 228-235 (2020)
Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B. FASEB Bioadv. 2, 49-58 (2020)
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. Structure. 10.1016/j.str.2020.01.005 (2020)
Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nat Chem Biol. 10.1038/s41589-020-0481-5 (2020)
Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 117, 4109-4116 (2020)
Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase. Elife. 10.7554/eLife.53473 (2020)
DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. FASEB J. 34, 4573-4590 (2020)
TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun. 11, 547 (2020)
Higher-Order Oligomerization of a Chimeric αβγ Bifunctional Diterpene Synthase with Prenyltransferase and Class II Cyclase Activities is Concentration-Dependent.. J Struct Biol. 10.1016/j.jsb.2020.107463 (2020)
Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses. J Exp Med. 10.1084/jem.20191155 (2020)
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 10.1016/j.molcel.2019.12.010 (2020)
Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J Med Chem. 63, 295-308 (2020)
A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Nucleic Acids Res. 48, 349-358 (2020)
Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. J Gen Physiol. 10.1085/jgp.201912422 (2020)
Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins. 87, 1037-1057 (2019)
Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases.. Commun Biol. 2, 354 (2019)
Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. ACS Med Chem Lett. 10, 1648-1654 (2019)
Structures of a RAG-like transposase during cut-and-paste transposition. Nature. 575, 540-544 (2019)