Publications

Xu, Y., Robev, D., Saha, N., Wang, B., Dalva, M. B., Xu, K., Himanen, J. P., and Nikolov, D. B. (2021) The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. Int J Mol Sci. 10.3390/ijms221910473
Yu, Y., Zheng, Q., Erramilli, S. K., Pan, M., Park, S., Xie, Y., Li, J., Fei, J., Kossiakoff, A. A., Liu, L., and Zhao, M. (2021) K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat Chem Biol. 17, 896-905
Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M., and Jin, R. (2021) Structural basis for selective modification of Rho and Ras GTPases by toxin B. Sci Adv. 7, eabi4582
Borowska, M. T., Drees, C., Yarawsky, A. E., Viswanathan, M., Ryan, S. M., Bunker, J. J., Herr, A. B., Bendelac, A., and Adams, E. J. (2021) The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 10.1073/pnas.2023898118
Waschbüsch, D., Berndsen, K., Lis, P., Knebel, A., Lam, Y. Py, Alessi, D. R., and Khan, A. R. (2021) Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO Rep. 10.15252/embr.202152675
Zahid, H., Buchholz, C. R., Singh, M., Ciccone, M. F., Chan, A., Nithianantham, S., Shi, K., Aihara, H., Fischer, M., Schönbrunn, E., Santos, C. O. Dos, Landry, J. W., and Pomerantz, W. C. K. (2021) New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J Med Chem. 64, 13902-13917
McCarthy, K. R., Lee, J., Watanabe, A., Kuraoka, M., Robinson-McCarthy, L. R., Georgiou, G., Kelsoe, G., and Harrison, S. C. (2021) A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. mBio. 12, e0114421
Lormand, J. D., Kim, S. - K., Walters-Marrah, G. A., Brownfield, B. A., J Fromme, C., Winkler, W. C., Goodson, J. R., Lee, V. T., and Sondermann, H. (2021) Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife. 10.7554/eLife.70146
Fenton, B. A., Tomberg, J., Sciandra, C. A., Nicholas, R. A., Davies, C., and Zhou, P. (2021) Mutations in PBP2 from Ceftriaxone-resistant Neisseria gonorrhoeae Alter the Dynamics of the β3-β4 Loop to Favor a Low-affinity Drug-binding State.. J Biol Chem. 10.1016/j.jbc.2021.101188
Patchett, S., Lv, Z., Rut, W., Békés, M., Drag, M., Olsen, S. K., and Huang, T. T. (2021) A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep. 36, 109754
Wang, W., Liu, Q., Liu, Q., and Hendrickson, W. A. (2021) Conformational equilibria in allosteric control of Hsp70 chaperones. Mol Cell. 10.1016/j.molcel.2021.07.039
Bowen, N. E., Temple, J., Shepard, C., Oo, A., Arizaga, F., Kapoor-Vazirani, P., Persaud, M., Yu, C. H., Kim, D. - H., Schinazi, R. F., Ivanov, D. N., Diaz-Griffero, F., Yu, D. S., Xiong, Y., and Kim, B. (2021) Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J Biol Chem. 10.1016/j.jbc.2021.101170
Vemulapalli, V., Donovan, K. A., Seegar, T. C. M., Rogers, J. M., Bae, M., Lumpkin, R. J., Cao, R., Henke, M. T., Ray, S. S., Fischer, E. S., Cuny, G. D., and Blacklow, S. C. (2021) Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry. 60, 2593-2609
Ochoa, J. M., Mijares, O., Acosta, A. A., Escoto, X., Leon-Rivera, N., Marshall, J. D., Sawaya, M. R., and Yeates, T. O. (2021) Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments. Acta Crystallogr F Struct Biol Commun. 77, 275-285
Ye, Q., Lu, S., and Corbett, K. D. (2021) Structural Basis for SARS-CoV-2 Nucleocapsid Protein Recognition by Single-Domain Antibodies. Front Immunol. 12, 719037
Castel, P., Dharmaiah, S., Sale, M. J., Messing, S., Rizzuto, G., Cuevas-Navarro, A., Cheng, A., Trnka, M. J., Urisman, A., Esposito, D., Simanshu, D. K., and McCormick, F. (2021) RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc Natl Acad Sci U S A. 10.1073/pnas.2103261118
Cui, H., Carlson, A. S., Schleiff, M. A., Divakaran, A., Johnson, J. A., Buchholz, C. R., Zahid, H., Vail, N. R., Shi, K., Aihara, H., Harki, D. A., Miller, G. P., Topczewski, J. J., and Pomerantz, W. C. K. (2021) 4-Methyl-1,2,3-Triazoles as -Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. J Med Chem. 64, 10497-10511
Zhang, C. - H., Spasov, K. A., Reilly, R. A., Hollander, K., Stone, E. A., Ippolito, J. A., Liosi, M. - E., Deshmukh, M. G., Tirado-Rives, J., Zhang, S., Liang, Z., Miller, S. J., Isaacs, F., Lindenbach, B. D., Anderson, K. S., and Jorgensen, W. L. (2021) Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency. ACS Med Chem Lett. 12, 1325-1332
Schwer, B., Garg, A., Jacewicz, A., and Shuman, S. (2021) Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1. Proc Natl Acad Sci U S A. 10.1073/pnas.2108105118
Ye, G., Gallant, J., Zheng, J., Massey, C., Shi, K., Tai, W., Odle, A., Vickers, M., Shang, J., Wan, Y., Du, L., Aihara, H., Perlman, S., LeBeau, A., and Li, F. (2021) The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates. Elife. 10.7554/eLife.64815
Roman, C., Lewicka, A., Koirala, D., Li, N. - S., and Piccirilli, J. A. (2021) The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography.. ACS Chem Biol. 10.1021/acschembio.1c00324
Slavik, K. M., Morehouse, B. R., Ragucci, A. E., Zhou, W., Ai, X., Chen, Y., Li, L., Wei, Z., Bähre, H., König, M., Seifert, R., S Y Lee, A., Cai, H., Imler, J. - L., and Kranzusch, P. J. (2021) cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature. 10.1038/s41586-021-03743-5
Deshmukh, M. G., Ippolito, J. A., Zhang, C. - H., Stone, E. A., Reilly, R. A., Miller, S. J., Jorgensen, W. L., and Anderson, K. S. (2021) Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease. Structure. 10.1016/j.str.2021.06.002
LoVerde, P. T., Alwan, S. N., Taylor, A. B., Rhodes, J., Chevalier, F. D., Anderson, T. Jc, and McHardy, S. F. (2021) Rational approach to drug discovery for human schistosomiasis. Int J Parasitol Drugs Drug Resist. 16, 140-147
Sahtoe, D. D., Coscia, A., Mustafaoglu, N., Miller, L. M., Olal, D., Vulovic, I., Yu, T. - Y., Goreshnik, I., Lin, Y. - R., Clark, L., Busch, F., Stewart, L., Wysocki, V. H., Ingber, D. E., Abraham, J., and Baker, D. (2021) Transferrin receptor targeting by de novo sheet extension. Proc Natl Acad Sci U S A. 10.1073/pnas.2021569118
Liew, J. J. M., Saudi, I. M. El, Nguyen, S. V., Wicht, D. K., and Dowling, D. P. (2021) Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer. J Biol Chem. 297, 100823
Deng, Y., Deng, S., Ho, Y. - H., Gardner, S. M., Huang, Z., Marmorstein, R., and Huang, R. (2021) Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D. J Med Chem. 10.1021/acs.jmedchem.1c00141
Blum, E., Zhang, J., Zaluski, J., Einstein, D. E., Korshin, E. E., Kubas, A., Gruzman, A., Tochtrop, G. P., Kiser, P. D., and Palczewski, K. (2021) Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 10.1021/acs.jmedchem.1c00279
Govande, A. A., Duncan-Lowey, B., Eaglesham, J. B., Whiteley, A. T., and Kranzusch, P. J. (2021) Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep. 35, 109206
Bogner, A. N., Stiers, K. M., McKay, C. M., Becker, D. F., and Tanner, J. J. (2021) Structural Basis for the Stereospecific Inhibition of the Dual Proline/Hydroxyproline Catabolic Enzyme ALDH4A1 by Trans-4-Hydroxy-L-Proline. Protein Sci. 10.1002/pro.4131
Joiner, A. M. N., and J Fromme, C. (2021) Structural basis for the initiation of COPII vesicle biogenesis. Structure. 10.1016/j.str.2021.03.013
Jobichen, C., Chong, T. Ying, Ling, T. Hui, and Sivaraman, J. (2021) The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from : A Structural Insight. Biochemistry. 60, 1564-1568
Chen, C. - W., Pavlova, J. A., Lukianov, D. A., Tereshchenkov, A. G., Makarov, G. I., Khairullina, Z. Z., Tashlitsky, V. N., Paleskava, A., Konevega, A. L., Bogdanov, A. A., Osterman, I. A., Sumbatyan, N. V., and Polikanov, Y. S. (2021) Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome. Antibiotics (Basel). 10.3390/antibiotics10040390
Lénon, M., Ke, N., Ren, G., Meuser, M. E., Loll, P. J., Riggs, P., and Berkmen, M. (2021) A useful epitope tag derived from maltose binding protein. Protein Sci. 10.1002/pro.4088
Doherty, E. E., Wilcox, X. E., Fiet, Lvan Sint, Kemmel, C., Turunen, J. J., Klein, B., Tantillo, D. J., Fisher, A. J., and Beal, P. A. (2021) Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J Am Chem Soc. 143, 6865-6876

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