PILATUS Publications
Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun. 13, 3669 (2022)
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat Struct Mol Biol. 29, 966-977 (2022)
Structure and mechanism of human cystine exporter cystinosin. Cell. 185, 3739-3752.e18 (2022)
Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase -Dimethylallyl-l-tryptophan Synthase from . Biochemistry. 10.1021/acs.biochem.2c00350 (2022)
Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1. Biochemistry. 61, 1723-1734 (2022)
Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases. Nucleic Acids Res. 50, 8807-8817 (2022)
Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response.. Front Immunol. 13, 847092 (2022)
Native SAD phasing at room temperature. Acta Crystallogr D Struct Biol. 78, 986-996 (2022)
The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PLoS Pathog. 18, e1010623 (2022)
Mechanistic basis for maintenance of CHG DNA methylation in plants. Nat Commun. 13, 3877 (2022)
Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun. 13, 4249 (2022)
Structure and activity of a bacterial defense-associated 3'-5' exonuclease. Protein Sci. 31, e4374 (2022)
Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways. J Biol Chem. 10.1016/j.jbc.2022.102111 (2022)
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat Struct Mol Biol. 29, 529-536 (2022)
Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 29, 537-548 (2022)
Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant. Proc Natl Acad Sci U S A. 119, e2122769119 (2022)
Structural and functional insight into mismatch extension by human DNA polymerase α.. Proc Natl Acad Sci U S A. 119, e2111744119 (2022)
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 185, 1157-1171.e22 (2022)
Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 234, 114272 (2022)
Structure and conformational dynamics of toxin A. Life Sci Alliance. 10.26508/lsa.202201383 (2022)
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Nat Commun. 13, 749 (2022)
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN. Proc Natl Acad Sci U S A. 10.1073/pnas.2106379119 (2022)
Bacterial gasdermins reveal an ancient mechanism of cell death. Science. 375, 221-225 (2022)
Structural basis for substrate binding and catalysis by a self-alkylating ribozyme. Nat Chem Biol. 10.1038/s41589-021-00950-z (2022)
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. J Med Chem. 10.1021/acs.jmedchem.1c01779 (2022)
Computational design of a synthetic PD-1 agonist. Proc Natl Acad Sci U S A. 10.1073/pnas.2102164118 (2021)
A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites. Structure. 29, 1128-1143.e4 (2021)
A conformational change in the N terminus of SLC38A9 signals mTORC1 activation. Structure. 29, 426-432.e8 (2021)
Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent. PLoS Biol. 19, e3001463 (2021)
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem. 10.1021/acs.jmedchem.1c00848 (2021)
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem. 64, 10849-10877 (2021)
Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain. Science (2021)
Intermediates in allosteric equilibria of DnaK-ATP interactions with substrate peptides. Acta Crystallogr D Struct Biol. 77, 606-617 (2021)
Crystal structure of the potato leafroll virus coat protein and implications for viral assembly. J Struct Biol. 214, 107811 (2021)
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense. Mol Cell. 10.1016/j.molcel.2021.10.020 (2021)