Publications

Found 92 results
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Tian, Y., Simanshu, D. K., Ma, J. - B., and Patel, D. J. (2011) Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. Proc Natl Acad Sci U S A. 108, 903-10
Ren, A., Wang, X. C., Kellenberger, C. A., Rajashankar, K. R., Jones, R. A., Hammond, M. C., and Patel, D. J. (2015) Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch. Cell Rep. 11, 1-12
Li, H., Fischle, W., Wang, W., Duncan, E. M., Liang, L., Murakami-Ishibe, S., C Allis, D., and Patel, D. J. (2007) Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell. 28, 677-91
Hoelper, D., Huang, H., Jain, A. Y., Patel, D. J., and Lewis, P. W. (2017) Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX. Nat Commun. 8, 1193
Ren, A., Xue, Y., Peselis, A., Serganov, A., Al-Hashimi, H. M., and Patel, D. J. (2015) Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep. 13, 1800-13
Sun, X. - J., Wang, Z., Wang, L., Jiang, Y., Kost, N., T Soong, D., Chen, W. - Y., Tang, Z., Nakadai, T., Elemento, O., Fischle, W., Melnick, A., Patel, D. J., Nimer, S. D., and Roeder, R. G. (2013) A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature. 500, 93-7
Oh, Y. - S., Gao, P., Lee, K. - W., Ceglia, I., Seo, J. - S., Zhang, X., Ahn, J. - H., Chait, B. T., Patel, D. J., Kim, Y., and Greengard, P. (2013) SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell. 152, 831-43
Minuesa, G., Albanese, S. K., Xie, W., Kazansky, Y., Worroll, D., Chow, A., Schurer, A., Park, S. - M., Rotsides, C. Z., Taggart, J., Rizzi, A., Naden, L. N., Chou, T., Gourkanti, S., Cappel, D., Passarelli, M. C., Fairchild, L., Adura, C., J Glickman, F., Schulman, J., Famulare, C., Patel, M., Eibl, J. K., Ross, G. M., Bhattacharya, S., Tan, D. S., Leslie, C. S., Beuming, T., Patel, D. J., Goldgur, Y., Chodera, J. D., and Kharas, M. G. (2019) Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 10, 2691
Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., Rothamel, K., Gogakos, T., Steinberg, J., Reasoner, S., Aso, K., Tuschl, T., Patel, D. J., J Glickman, F., and Ascano, M. (2017) Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 8, 750
Kruidenier, L., Chung, C. -wa, Cheng, Z., Liddle, J., Che, K. H., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., Eberhard, D., Hutchinson, S., Jones, E., Katso, R., Leveridge, M., Mander, P. K., Mosley, J., Ramirez-Molina, C., Rowland, P., Schofield, C. J., Sheppard, R. J., Smith, J. E., Swales, C., Tanner, R., Thomas, P., Tumber, A., Drewes, G., Oppermann, U., Patel, D. J., Lee, K., and Wilson, D. M. (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 488, 404-8
Jia, N., Jones, R., Sukenick, G., and Patel, D. J. (2019) Second Messenger cA Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol Cell. 75, 933-943.e6
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Chen, S., Yang, Z., Wilkinson, A. W., Deshpande, A. J., Sidoli, S., Krajewski, K., Strahl, B. D., Garcia, B. A., Armstrong, S. A., Patel, D. J., and Gozani, O. (2015) The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol Cell. 60, 319-27
Wang, Z., Song, J., Milne, T. A., Wang, G. G., Li, H., C Allis, D., and Patel, D. J. (2010) Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell. 141, 1183-94
Law, J. A., Du, J., Hale, C. J., Feng, S., Krajewski, K., Palanca, A. Marie S., Strahl, B. D., Patel, D. J., and Jacobsen, S. E. (2013) Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 498, 385-9
Xi, Q., Wang, Z., Zaromytidou, A. - I., Zhang, X. H. - F., Chow-Tsang, L. - F., Liu, J. X., Kim, H., Barlas, A., Manova-Todorova, K., Kaartinen, V., Studer, L., Mark, W., Patel, D. J., and Massagué, J. (2011) A poised chromatin platform for TGF-β access to master regulators.. Cell. 147, 1511-24
Tian, Y., Simanshu, D. K., Ma, J. - B., Park, J. - E., Heo, I., V Kim, N., and Patel, D. J. (2014) A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Mol Cell. 53, 606-16
Rajakumara, E., Wang, Z., Ma, H., Hu, L., Chen, H., Lin, Y., Guo, R., Wu, F., Li, H., Lan, F., Shi, Y. Geno, Xu, Y., Patel, D. J., and Shi, Y. (2011) PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Mol Cell. 43, 275-284
Yang, H., Gao, P., Rajashankar, K. R., and Patel, D. J. (2016) PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. Cell. 167, 1814-1828.e12

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