Research Highlights
![Structure of mouse RECON (AKR1C13) in complex with cyclic AMP-AMP-GMP (cAAG) Structure of mouse RECON (AKR1C13) in complex with cyclic AMP-AMP-GMP (cAAG)](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6m7k.pdb1-500_0.jpg?itok=fI-0fieB)
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 10.1038/s41586-019-0953-5 (2019)
![Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3'] Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6ea9.pdb1-500_0.jpg?itok=g_h_U9hi)
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 566, 259-263 (2019)
![Crystal structure of LRRK2 WD40 domain dimer Crystal structure of LRRK2 WD40 domain dimer](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6dlo.pdb-500.jpg?itok=-3v3yZRG)
Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 10.1073/pnas.1817889116 (2019)
![6MZE 6MZE](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6mze.pdb1-500.jpg?itok=_UV6Ez9U)
Structural basis of tubulin recruitment and assembly by microtubule polymerases with Tumor Overexpressed Gene (TOG) domain arrays. Elife. 10.7554/eLife.38922 (2018)
![Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase, as-isolated (protein batch 1), canonical C-cluster Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase, as-isolated (protein batch 1), canonical C-cluster](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6b6v.pdb1-500.jpg?itok=KJAB_U9u)
Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife. 10.7554/eLife.39451 (2018)
![6CT9 6CT9 Ribbon](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6ct9.pdb1-500.jpg?itok=h1i1DySV)
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 174, 300-311.e11 (2018)
![6CAE 6CAE](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6cae.pdb1-500.jpg?itok=sWcCbx4S)
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol Cell. 70, 83-94.e7 (2018)
![6AWO 6AWO](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/6awo.pdb1-500.jpg?itok=7TPUEHyr)
Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat Struct Mol Biol. 10.1038/s41594-018-0026-8 (2018)
![5VAQ 5VAQ](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/5vaq.pdb-500.jpg?itok=Vl8MAJdR)
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.. Nature. 10.1038/nature25010 (2018)
Non-specific activities of the major herbicide-resistance gene BAR. Nat Plants. 3, 937-945 (2017)
Structural basis for methylphosphonate biosynthesis. Science. 358, 1336-1339 (2017)
How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration. Nature. 550, 137-141 (2017)
![Structure on the Cover of Nature Structure on the Cover of Nature](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/cover_nature.jpg?itok=hdy3b1Af)
The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature. 10.1038/nature23484 (2017)
Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9. Mol Cell. 10.1016/j.molcel.2017.05.024 (2017)
RNA polymerase motions during promoter melting. Science. 356, 863-866 (2017)
![Hfq homolog on the Cover of Acta Cryst. D from Twitter Cover Image from Twitter](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/C9yG6a9XsAE-jhV.jpg-large.jpeg?itok=Mw841Ip9)
Crystal structure and RNA-binding properties of an Hfq homolog from the deep-branching Aquificae: conservation of the lateral RNA-binding mode. Acta Crystallogr D Struct Biol. 73, 294-315 (2017)
![Cover of March 2017 Issue of Toxins Cover to March Issue of Toxins](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/%5BToxins%5D%20Cover%20for%20I3%2C%20V9-HD-Final%202.jpg?itok=kwDOlz1K)
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel). 10.3390/toxins9030093 (2017)
![Biological Assembly of 5TOD 5TOD Biological Assembly 7](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/5TOD_bio_r_500.jpg?itok=cFqKJGTl)
Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science. 10.1126/science.aah6171 (2017)
![Cover of Nature Structure & Molecular Biology for February 2017 Cover of Nature Structure & Molecular Biology for February 2017](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/largecover.gif?itok=Iq2U1v3L)
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nat Struct Mol Biol. 24, 131-139 (2017)
![5T77 Biological Subunit 5T77 Biological Subunit](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/5T77_bio_r_500.jpg?itok=7FqmPmVT)
Crystal structure of the MOP flippase MurJ in an inward-facing conformation. Nat Struct Mol Biol. 24, 171-176 (2017)
![AacC2c1-sgRNA-DNA Ternary Complex AacC2c1-sgRNA-DNA Ternary Complex](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/1-s2.0-S0092867416316658-fx1.jpg?itok=ZtcibFpA)
PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. Cell. 167, 1814-1828.e12 (2016)
![5JLV 5JLV](https://lilith.nec.aps.anl.gov/sites/default/files/styles/medium/public/5JLV_bio_r_500.jpg?itok=_etTzR6g)
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 23, 656-62 (2016)
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