Publications

Found 22 results
Filters: Author is Darst, Seth A  [Clear All Filters]
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Liu, Z., Frutos, S., Bick, M. J., Vila-Perelló, M., Debelouchina, G. T., Darst, S. A., and Muir, T. W. (2014) Structure of the branched intermediate in protein splicing. Proc Natl Acad Sci U S A. 111, 8422-7
Bae, B., Feklistov, A., Lass-Napiorkowska, A., Landick, R., and Darst, S. A. (2015) Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife. 10.7554/eLife.08504
Hubin, E. A., Fay, A., Xu, C., Bean, J. M., Saecker, R. M., Glickman, M. S., Darst, S. A., and Campbell, E. A. (2017) Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA. Elife. 10.7554/eLife.22520
Braffman, N. R., Piscotta, F. J., Hauver, J., Campbell, E. A., A Link, J., and Darst, S. A. (2019) Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc Natl Acad Sci U S A. 116, 1273-1278
Hubin, E. A., Lilic, M., Darst, S. A., and Campbell, E. A. (2017) Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun. 8, 16072
Weixlbaumer, A., Leon, K., Landick, R., and Darst, S. A. (2013) Structural basis of transcriptional pausing in bacteria. Cell. 152, 431-41
Westblade, L. F., Campbell, E. A., Pukhrambam, C., Padovan, J. C., Nickels, B. E., Lamour, V., and Darst, S. A. (2010) Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction. Nucleic Acids Res. 38, 8357-69
Feklistov, A., and Darst, S. A. (2011) Structural basis for promoter-10 element recognition by the bacterial RNA polymerase σ subunit.. Cell. 147, 1257-69
Deaconescu, A. M., Chambers, A. L., Smith, A. J., Nickels, B. E., Hochschild, A., Savery, N. J., and Darst, S. A. (2006) Structural basis for bacterial transcription-coupled DNA repair. Cell. 124, 507-20
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Feklistov, A., Bae, B., Hauver, J., Lass-Napiorkowska, A., Kalesse, M., Glaus, F., Altmann, K. - H., Heyduk, T., Landick, R., and Darst, S. A. (2017) RNA polymerase motions during promoter melting. Science. 356, 863-866
Peek, J., Lilic, M., Montiel, D., Milshteyn, A., Woodworth, I., Biggins, J. B., Ternei, M. A., Calle, P. Y., Danziger, M., Warrier, T., Saito, K., Braffman, N., Fay, A., Glickman, M. S., Darst, S. A., Campbell, E. A., and Brady, S. F. (2018) Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun. 9, 4147
Kuznedelov, K., Lamour, V., Patikoglou, G., Chlenov, M., Darst, S. A., and Severinov, K. (2006) Recombinant Thermus aquaticus RNA polymerase for structural studies. J Mol Biol. 359, 110-21
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Osmundson, J., Montero-Diez, C., Westblade, L. F., Hochschild, A., and Darst, S. A. (2012) Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell. 151, 1005-16
Bae, B., Davis, E., Brown, D., Campbell, E. A., Wigneshweraraj, S., and Darst, S. A. (2013) Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1.. Proc Natl Acad Sci U S A. 110, 19772-7
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Subramanian, R., Ti, S. - C., Tan, L., Darst, S. A., and Kapoor, T. M. (2013) Marking and measuring single microtubules by PRC1 and kinesin-4. Cell. 154, 377-90
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Subramanian, R., Wilson-Kubalek, E. M., Arthur, C. P., Bick, M. J., Campbell, E. A., Darst, S. A., Milligan, R. A., and Kapoor, T. M. (2010) Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell. 142, 433-43
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Bick, M. J., Lamour, V., Rajashankar, K. R., Gordiyenko, Y., Robinson, C. V., and Darst, S. A. (2009) How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda. J Mol Biol. 386, 163-77
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Feklistov, A., and Darst, S. A. (2013) Crystallographic analysis of an RNA polymerase σ-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes.. Acta Crystallogr Sect F Struct Biol Cryst Commun. 69, 950-5
Deaconescu, A. M., and Darst, S. A. (2005) Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor. Acta Crystallogr Sect F Struct Biol Cryst Commun. 61, 1062-4
Bick, M. J., Banik, J. J., Darst, S. A., and Brady, S. F. (2010) Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry. 49, 4159-68
Campbell, E. A., Kamath, S., Rajashankar, K. R., Wu, M., and Darst, S. A. (2017) Crystal structure of Aquifex aeolicus σ(N) bound to promoter DNA and the structure of σ(N)-holoenzyme.. Proc Natl Acad Sci U S A. 114, E1805-E1814
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Lilic, M., Chen, J., Boyaci, H., Braffman, N., Hubin, E. A., Herrmann, J., Müller, R., Mooney, R., Landick, R., Darst, S. A., and Campbell, E. A. (2020) The antibiotic sorangicin A inhibits promoter DNA unwinding in a rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A. 117, 30423-30432