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Zhao, J., C Cochrane, S., Najeeb, J., Gooden, D., Sciandra, C., Fan, P., Lemaitre, N., Newns, K., Nicholas, R. A., Guan, Z., Thaden, J. T., Fowler, V. G., Spasojevic, I., Sebbane, F., Toone, E. J., Duncan, C., Gammans, R., and Zhou, P. (2023) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med. 15, eadf5668
Zhao, J., C Cochrane, S., Najeeb, J., Gooden, D., Sciandra, C., Fan, P., Lemaitre, N., Newns, K., Nicholas, R. A., Guan, Z., Thaden, J. T., Fowler, V. G., Spasojevic, I., Sebbane, F., Toone, E. J., Duncan, C., Gammans, R., and Zhou, P. (2023) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med. 15, eadf5668
Zhao, J., C Cochrane, S., Najeeb, J., Gooden, D., Sciandra, C., Fan, P., Lemaitre, N., Newns, K., Nicholas, R. A., Guan, Z., Thaden, J. T., Fowler, V. G., Spasojevic, I., Sebbane, F., Toone, E. J., Duncan, C., Gammans, R., and Zhou, P. (2023) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med. 15, eadf5668
Khare, B., Samal, A., Vengadesan, K., Rajashankar, K. R., Ma, X., I Huang, H., Ton-That, H., and Narayana, S. V. L. (2010) Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66, 1096-100
Englert, M., Nakamura, A., Wang, Y. - S., Eiler, D., Söll, D., and Guo, L. - T. (2015) Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog. Nucleic Acids Res. 43, 11061-7
Sawaya, M. R., Cascio, D., Gingery, M., Rodriguez, J., Goldschmidt, L., Colletier, J. - P., Messerschmidt, M. M., Boutet, S., Koglin, J. E., Williams, G. J., Brewster, A. S., Nass, K., Hattne, J., Botha, S., R Doak, B., Shoeman, R. L., DePonte, D. P., Park, H. - W., Federici, B. A., Sauter, N. K., Schlichting, I., and Eisenberg, D. S. (2014) Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam.. Proc Natl Acad Sci U S A. 111, 12769-74
Novikova, I. V., Sharma, N., Moser, T., Sontag, R., Liu, Y., Collazo, M. J., Cascio, D., Shokuhfar, T., Hellmann, H., Knoblauch, M., and Evans, J. E. (2018) Protein structural biology using cell-free platform from wheat germ. Adv Struct Chem Imaging. 4, 13
Wolfe, L. S., Calabrese, M. F., Nath, A., Blaho, D. V., Miranker, A. D., and Xiong, Y. (2010) Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proc Natl Acad Sci U S A. 107, 16863-8
Nelersa, C. M., Schmier, B. J., and Malhotra, A. (2011) Purification and crystallization of Bacillus subtilis NrnA, a novel enzyme involved in nanoRNA degradation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67, 1235-8
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Roark, R. S., Li, H., Williams, W. B., Chug, H., Mason, R. D., Gorman, J., Wang, S., Lee, F. - H., Rando, J., Bonsignori, M., Hwang, K. - K., Saunders, K. O., Wiehe, K., M Moody, A., Hraber, P. T., Wagh, K., Giorgi, E. E., Russell, R. M., Bibollet-Ruche, F., Liu, W., Connell, J., Smith, A. G., DeVoto, J., Murphy, A. I., Smith, J., Ding, W., Zhao, C., Chohan, N., Okumura, M., Rosario, C., Ding, Y., Lindemuth, E., Bauer, A. M., Bar, K. J., Ambrozak, D., Chao, C. W., Chuang, G. - Y., Geng, H., Lin, B. C., Louder, M. K., Nguyen, R., Zhang, B., Lewis, M. G., Raymond, D., Doria-Rose, N. A., Schramm, C. A., Douek, D. C., Roederer, M., Kepler, T. B., Kelsoe, G., Mascola, J. R., Kwong, P. D., Korber, B. T., Harrison, S. C., Haynes, B. F., Hahn, B. H., and Shaw, G. M. (2020) Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science. 10.1126/science.abd2638
Neau, D. (2014) Recent Developments at NE-CAT, a Macromolecular Crystallography Synchrotron Facility. Indo-US International Conference/Workshop on Recent Advances in Structural Biology and Drug Discovery, October 9-11, 2014
MacDonald, E. A., Frey, G., Namchuk, M. N., Harrison, S. C., Hinshaw, S. M., and Windsor, I. W. (2021) Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease. ACS Infect Dis. 10.1021/acsinfecdis.1c00237
Wan, L. C. K., Mao, D. Y. L., Neculai, D., Strecker, J., Chiovitti, D., Kurinov, I., Poda, G., Thevakumaran, N., Yuan, F., Szilard, R. K., Lissina, E., Nislow, C., Caudy, A. A., Durocher, D., and Sicheri, F. (2013) Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res. 41, 6332-46
Wan, L. C. K., Mao, D. Y. L., Neculai, D., Strecker, J., Chiovitti, D., Kurinov, I., Poda, G., Thevakumaran, N., Yuan, F., Szilard, R. K., Lissina, E., Nislow, C., Caudy, A. A., Durocher, D., and Sicheri, F. (2013) Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res. 41, 6332-46
Chao, F. - A., Chan, A. H., Dharmaiah, S., Schwieters, C. D., Tran, T. H., Taylor, T., Ramakrishnan, N., Esposito, D., Nissley, D. V., McCormick, F., Simanshu, D. K., and Cornilescu, G. (2023) Reduced dynamic complexity allows structure elucidation of an excited state of KRAS. Commun Biol. 6, 594
Nandakumar, J., Shuman, S., and Lima, C. D. (2006) RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell. 127, 71-84
Nguyen, T., Lee, S., Yang, Y. - A., Ahn, C., Sim, J. Hyun, Kei, T. G., Barnard, K. N., Yu, H., Millano, S. K., Chen, X., Parrish, C. R., and Song, J. (2020) The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication. PLoS Pathog. 16, e1008336
Shi, F., Mendrola, J. M., Sheetz, J. B., Wu, N., Sommer, A., Speer, K. F., Noordermeer, J. N., Kan, Z. - Y., Perry, K., S Englander, W., Stayrook, S. E., Fradkin, L. G., and Lemmon, M. A. (2021) ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Rep. 37, 109834
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Liosi, M. - E., Krimmer, S. G., Newton, A. S., Dawson, T., Puleo, D. E., Cutrona, K. J., Suzuki, Y., Schlessinger, J., and Jorgensen, W. L. (2020) Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. J Med Chem. 10.1021/acs.jmedchem.0c00192
Zeller, M. J., Favorov, O., Li, K., Nuthanakanti, A., Hussein, D., Michaud, A., Lafontaine, D. A., Busan, S., Serganov, A., Aubé, J., and Weeks, K. M. (2022) SHAPE-enabled fragment-based ligand discovery for RNA. Proc Natl Acad Sci U S A. 119, e2122660119
Fram, B., Truebridge, I., Su, Y., Riesselman, A. J., Ingraham, J. B., Passera, A., Napier, E., Thadani, N. N., Lim, S., Roberts, K., Kaur, G., Stiffler, M., Marks, D. S., Bahl, C. D., Khan, A. R., Sander, C., and Gauthier, N. P. (2023) Simultaneous enhancement of multiple functional properties using evolution-informed protein design. bioRxiv. 10.1101/2023.05.09.539914
Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K. Joshua, Zhang, M., Zhao, D. Yanling, Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P. J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M. T., Greenblatt, J. F., and Min, J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
Cavalier, M. C., Ansari, M. Imran, Pierce, A. D., Wilder, P. T., McKnight, L. E., E Raman, P., Neau, D. B., Bezawada, P., Alasady, M. J., Charpentier, T. H., Varney, K. M., Toth, E. A., MacKerell, A. D., Coop, A., and Weber, D. J. (2016) Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. J Med Chem. 59, 592-608
Minuesa, G., Albanese, S. K., Xie, W., Kazansky, Y., Worroll, D., Chow, A., Schurer, A., Park, S. - M., Rotsides, C. Z., Taggart, J., Rizzi, A., Naden, L. N., Chou, T., Gourkanti, S., Cappel, D., Passarelli, M. C., Fairchild, L., Adura, C., J Glickman, F., Schulman, J., Famulare, C., Patel, M., Eibl, J. K., Ross, G. M., Bhattacharya, S., Tan, D. S., Leslie, C. S., Beuming, T., Patel, D. J., Goldgur, Y., Chodera, J. D., and Kharas, M. G. (2019) Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 10, 2691
Liu, H., Wang, C., Lee, S., Ning, F., Wang, Y., Zhang, Q., Chen, Z., Zang, J., Nix, J., Dai, S., Marrack, P., Hagman, J., Kappler, J., and Zhang, G. (2018) Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep. 8, 3275

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